Study on Effects of Jinhua Qinggan Granules in the Treatment of COVID-19 based on Network Pharmacology
(2.Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China 510405)
【Abstract】 Objective To explore the mechanism of Jinhua Qinggan Granules in treating COVID-19. Methods According to ADME characteristics of drugs, the active compounds and targets of Jinhua Qinggan Granules were screened by TCMSP platform. The component target network was constructed. The related targets of COVID-19 were retrieved based on GeneCards database. The protein-protein interaction (PPI) network was constructed by STRING database and the key targets were screened by Cytoscape software. The obtained target information was analyzed using DAVID database to analyze biological processes and pathway enrichment. Results 263 targets of Jinhua Qinggan Granules and 346 COVID-19 related target genes were screened out, and the mapping resulted in 49 common genes. The important gene targets were IL6, IL1β, CXCL8, CCL2, IL2, IL4, ICAM1, IL10, IFNG, and IL1 A. The GO analysis results showed that the biological processes mainly included cytokine activity, MAP kinase activity, chemokine activity, inflammatory response, and immune response. KEGG pathway analysis showed that Jinhua Qinggan Granules’ signaling pathways for the treatment of COVID-19 mainly included TNF signaling pathway, influenza A, HIF-1 signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway, MAPK signaling pathway, and T cell receptor signaling pathway. Conclusion Jinhua Qinggan Granules exert the therapeutic effects on COVID-19 by acting on multiple targets and multiple pathways to regulate the immunity and reduce inflammation, but its mechanism still needs to be confirmed by experiments.
【Keywords】 Jinhua Qinggan Granules; COVID-19; Network pharmacology; Mechanism of action;
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