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朱继孝1 史亚夫1 程虹毓2 王洪玲1 王瑞1 李敏1

(1.江西中医药大学中药资源与民族药研究中心, 江西南昌 330004)
(2.江西中医药大学人文学院, 江西南昌 330004)

【摘要】目的:研究短穗兔耳草的化学成分。方法:短穗兔耳草以75%乙醇提取,并采用硅胶柱层析、Sephadex LH-20、制备液相色谱、ODS等色谱柱和重结晶等方法进行分离纯化,通过波谱解析进行化学结构鉴定。结果:从短穗兔耳草中分离得到11个化合物,分别鉴定为:scutellariosidⅡ(1)、globularimin(2)、baldaccioside(3)、10-O-反式-异阿魏酰基梓醇(4)、8-epi-loganic acid(5)、木犀草素-7-O-β-D-吡喃葡萄糖苷(6)、小麦黄素-7-O-β-D-吡喃葡萄糖苷(7)、木犀草素(8)、hemiphroside B(9)、车前草苷D(10)、苯甲醇-O-(2′-O-β-D-吡喃木糖基)-β-D-吡喃葡萄糖苷(11)。结论:其中,化合物3、4、9、10、11为首次从该属植物中分离得到,化合物1、2、5、7为首次从该植物中分离得到。

【关键词】 短穗兔耳草;化学成分;结构鉴定;


【基金资助】 国家自然科学基金(81660702); “江西民族药现代科技与产业发展协同创新中心”开放基金(J XXT2017004);

Chemical Constituents from Lagotis brachystachy

ZHU Ji-xiao1 SHI Ya-fu1 CHENG Hong-yu2 WANG Hong-ling1 WANG Rui1 LI Min1

(1.Research Center of Chinese Herbal Medicine and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, China 330004)
(2.School of Humanities, Jiangxi University of Traditional Chinese Medicine, Nanchang, China 330004)

【Abstract】Objective: To study the chemical constituents of Lagotis brachystachy. Methods: L. brachystachy was extracted with 75% ethanol and isolated and purified by silica gel, Sephadex LH-20, preparative liquid chromatography, ODS column chromatography, and recrystallization. The chemical structures were identified by spectrum analysis. Results: Eleven compounds were isolated and identified as scutellariosid II (1), globularimin (2), baldaccioside (3), 10-O-trans-isoferoylcatalpol (4), 8-epi-loganic acid (5), luteolin-7-O-β-D-glucopyranoside (6), tricin-7-O-β-D-glucopyranoside (7), luteolin (8), hemiphroside B (9), plantaginin D (10), benzyl alcohol-O-(2′-O-β-D-pyranoxylol)-β-D-glucopyranoside (11). Conclusion: Compounds 3, 4, 9, 10, and 11 are isolated from the Logotis genus for the first time. Compounds 1, 2, 5, and 7 are isolated from L. brachystachy for the first time.

【Keywords】 Lagotis brachystachy Maxim.; Chemical constituents; Structural identification;


【Funds】 National Natural Science Foundation of China (81660702); Open Fund of Jiangxi Collaborative Innovation Center of Modern Technology and Industrial Development of Ethnic Medicine (JXXT2017004);

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    [1] Zhong BQ. Flora Reipublicae Popularis Sinicae [M]. Volume 67 (2). Beijing: Science Press, 1979: 327 (in Chinese).

    [2] 格尔·格桑扎西. 实用藏药名库 [M]. Xining: Qinghai Ethnic Publishing House, 2006: 89 (in Chinese).

    [3] Sudo H, Ide T, Otsuka H, et al. 10-O-acylated iridoid glucosides from leaves of Premna subscandens [J]. Phytochemistry, 1997, 46 (7): 1231–1236.

    [4] Yang XD, Zhao JF, Yang LJ, et al. Study on identification of iridoid glucosides from Lagotis yunnanesis [J]. Chinese Pharmaceutical Journal, 2004, 39 (2): 101–103 (in Chinese).

    [5] Taskova RM, Gotfredsen CH, Jensen SR. Chemotaxonomy of Veroniceae and its allies in the Plantaginaceae [J]. Phytochemistry, 2006, 67 (3): 286–301.

    [6] Dinda B, Debnath S, Harigaya Y. Naturally occurring iridoids. A review, part 1 [J]. Cheminform, 2007, 55 (2): 159–222.

    [7] Yuan CS, Zhang Q, Xie WD, et al. Iridoids from Pedicularis kansuensis forma albiflora [J]. Pharmazie, 2003, 58 (6): 428–430.

    [8] Shabana M, Gonaid M, Salama MM, et al. Phenylalkylamine alkaloids from Stapelia hirsuta L. [J]. Natural Product Research, 2006, 20 (8): 710–714.

    [9] Yang YC, He L, Yang AM, et al. 藏药短穗兔耳草化学成分研究 [J]. China Journal of Chinese Materia Medica, 2005, 30 (2): 153–154 (in Chinese).

    [10] Liu Y, Huang ZS, Xiao JG, et al. The purification, identification an biological activity of metabolites capable fo inducing Agrobacterium vir gene expression isolated from rice (Oryza sative L.) [J]. Chinese Journal of Organic Chemistry, 1995, 15 (1): 72–75 (in Chinese).

    [11] Thien TVN, Tran LTK, Nhu NTTt, et al. A new eudesmane-type sesquiterpene from the leaves of Artemisia vulgaris [J]. Chemistry of Natural Compounds, 2018, 54 (1): 66–68.

    [12] Ma WG, Li XC, Liu YQ, et al. Phenylpropanoid and iridoid glucosides from Hemiphragma heterophyllum [J]. Acta Botanical Yunnanica, 1997, 17 (1): 96–102 (in Chinese).

    [13] Duan WJ, Bai AY, Lin XP, et al. Isolation and purification of highly polar antioxidants from Chirita longgangensis, by combination of macroporous resin and HSCCC [J]. Chrom atographia, 2014, 77 (9–10): 707–713.

    [14] Sudo H, Ide T, Otsuka H, et al. Megastigmane, benzyl and phenethyl alcohol glycosides, and 4,4′-dimethoxy-β-truxinic acid catalpoldiester from the leaves of Premna subscandens Merr. [J]. Chemical & Pharmaceutical Bulletin, 2000, 48 (4): 542–546.

This Article


CN: 44-1286/R

Vol 42, No. 03, Pages 552-555

March 2019


Article Outline


  • 1 Instruments and materials
  • 2 Extraction and isolation
  • 3 Structure identification
  • References