Systematic evaluation and Meta-analysis of efficacy and safety of Tianzhi Granules in treatment of vascular cognitive impairment

HU Wen-yue1 HAN Zhen-yun1 MA Hua-ping1 LIN Jing-feng1 CHANG Ze1

(1.Beijing University of Chinese Medicine, Beijing, China 100029)

【Abstract】Tianzhi Granules have the effects of extinguishing liver wind, tonifying liver and kidney, and activating blood. At present, it is mainly used for the treatment of vascular cognitive impairment (VCI). However, its efficacy and safety remain to be verified. Therefore, this study aimed to systematically analyze the efficacy and safety of Tianzhi Granules in the treatment of VCI. The databases including China National Knowledge Infrastructure (CNKI), Chongqing Weipu Database for Chinese Technical Periodicals (VIP), Wanfang Data Knowledge Service Platform, Chinese Biomedical Literature Service System (SinoMed), PubMed, and Cochrane Library were searched to obtain the published articles. The ClinicalTrials.gov was also searched to figure out the completed but unpublished trials according to the inclusion criteria. Two researchers independently used the risk of bias assessment tools for quality assessment, and extracted and checked the data. Cochrane systematic evaluation software RevMan 5.3 was used for data analysis. Twenty-seven articles involving 2 741 subjects were included. The intervention measure was monotherapy with Tianzhi Granules, and the control measure was monotherapy with western medicine or blank control. According to the results, Tianzhi Granules were better than blank control and brain metabolism promoter in improving the clinical efficacy rate and MMSE score, and better than blank control and nimodipine in improving the event-related potential P300. Within three months, Tianzhi Granules had better effects than western medicine and blank control, and the incidence of adverse events was lower. Tianzhi Granules can be recommended for clinical application. However, due to the low quality of the included articles, these potential benefits need to be confirmed in future standardized clinical trials with a large sample size.

【Keywords】 Tianzhi Granules; vascular cognitive impairment; systematic review; Meta-analysis;

【DOI】

【Funds】 National Natural Science Foundation of China (81673910)

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This Article

ISSN:1001-5302

CN: 11-2272/R

Vol 45, No. 19, Pages 4766-4775

October 2020

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Article Outline

Abstract

  • 1 Materials and methods
  • 2 Results
  • 3 Discussion
  • 4 Limitations and disadvantages
  • References