Mechanism of traditional Chinese medicine balancing Yin-Yang by targeting ERα/ERβ and its application in treatment of menopausal syndrome

ZHAO Pi-wen1 WANG Yan-xia2 NIU Jian-zhao3

(1.School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China 100029)
(2.Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China 100700)
(3.School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China 100029)
【Knowledge Link】Alzheimer's disease

【Abstract】The coordination and unification of Yin and Yang are the basis of normal human life activities. Along with the increase of age and the aging of the body, women will suffer from menopausal syndrome during menopause. In addition to the significant changes in the genital system, there are also pathological manifestations in estrogen target points including bone, nerve, and cardiovascular systems, due to the imbalance of Yin and Yang. Besides the insufficiency of estrogen, the main cause of menopausal syndrome is the changes in the response of target organs to estrogen. In other words, the biological effects mediated by estrogen receptor (ER) alpha and beta subtypes in target cells are often different or even opposite, and the changes in expression of ERα and ERβ and their ratio are also important causes for the abnormal estrogenic effects in target organs as well as unbalanced Yin and Yang of the body. Therefore, on the one hand, the therapeutic mechanism of drugs is ER-mediated estrogenic effect. On the other hand, the drugs have a regulatory effect on ER subtype expression in target cells and Yin-Yang state in target organs and even organisms, so as to cause further changes in the response of target cells to estrogen or estrogenic components and exert the therapeutic effects. This paper reviews the pharmacological mechanism of traditional Chinese medicine for gynecological disease treatment in harmonizing Yin and Yang in estrogen-positive target cells and exerting clinical efficacy in the following aspects: estrogen and its mechanism, the role of ER in producing estrogenic effect by traditional Chinese medicine, and the mechanism of ER subtype in balancing Yin and Yang and mediating and regulating the main target tissues in menopausal syndrome treatment.

【Keywords】 traditional Chinese medicine; menopausal syndrome; estrogen receptor alpha/estrogen receptor beta; balancing Yin-Yang;

【DOI】

【Funds】 National Natural Science Foundation of China (81673764) Project of Ministry of Education & State Administration of Foreign Experts Affairs of China (B07007)

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(Translated by WU XX)

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This Article

ISSN:1001-5302

CN:11-2272/R

Vol 45, No. 16, Pages 3770-3775

August 2020

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Article Outline

Knowledge

Abstract

  • 1 Estrogen and its mechanism of action
  • 2 The estrogen-like effect of TCM in the treatment of menopausal syndrome and the Yin-Yang balance mechanism based on ER subtypes
  • 3 Conclusion
  • References