Meta-analysis of Ganmao Qingre Granules in treatment of children with wind-cold syndrome

HUANG Yan1,2 LYU Jian1 XIE Yan-ming1 SUN Meng-hua1

(1.Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China 100700)
(2. Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China 100700)

【Abstract】To systematically evaluate the efficacy and safety of Ganmao Qingre Granules in treatment of children with wind-cold syndrome. The study systematically retrieved CNKI, Wanfang, VIP, CBM, PubMed, EMbase, and Cochrane Library for RCTs with Ganmao Qingre Granules in the treatment of children with wind-cold syndrome. The literature inclusion criteria provided by Cochrane was used to evaluate the literature quality, and meta-analysis was conducted by RevMan 5.3 software. A total of six articles were included, with a total sample size of 492 cases, including 246 cases in the treatment group and 246 cases in the control group. According to the results of meta-analysis, the treatment group recorded the time of fever reduction (MD = −0.38, 95% CI [−0.53, −0.23], P < 0.01), total clinical effective rate (RR = 1.25, 95% CI [1.15, 1.36], P < 0.01), time of cough relief (MD = −2.75, 95% CI [−3.05, −2.46], P < 0.01), time of nasal congestion relief (MD = −1.45, 95% CI [−1.69, −1.22], P < 0.01), and traditional Chinese medicine syndrome score (MD = −8.35, 95% CI [−9.35, −7.36], P < 0.01), and all of them were superior to those of the control group (Xiao’er Anfen Huangnamin Granules, pediatric paracetamol, artificial cow-bezoar and chlorphenamine maleate), with statistically significant differences. Only two articles mentioned that no obvious adverse reaction occurred, and the other four did not report any adverse reaction. Based on the results of this study, it was suggested that Ganmao Qingre Granules were effective in the treatment of children with wind-cold syndrome, but with unclear adverse reactions. Due to the insufficient quantity and relatively low quality of included articles, the efficacy and safety need to be further confirmed by high-quality clinical studies.

【Keywords】 Ganmao Qingre Granules; children with wind-cold syndrome; Meta-analysis; efficacy; safety;

【DOI】

【Funds】 National Key R&D Program (2018YFC1707400, 2018YFC1707410) Project of Basic Research and Operation Expenses of Central-level Public Welfare Research Institutes (Z0605)

Download this article

(Translated by HAO DC)

    References

    [1] MA R. Clinical practice guide of traditional Chinese medicine alone/combined with antibiotics in the treatment of children with acute upper respiratory tract infection [C]. Jilin: The 19th annual meeting of China Association for Science and Technology—Forum on standards leading academic innovation and development of traditional Chinese Medicine, 2017 (in Chinese).

    [2] BAI Y, LI Y X, SHI Y J, et al. Meta-analysis on effectiveness and safety of Pudilan Xiaoyan Oral Liquid on child upper respiratory infection [J]. China Journal of Chinese Materia Medica, 2020, 45 (9): 2203 (in Chinese).

    [3] LI L, LIAO X, ZHAO J, et al. Interpretation of Chinese clinical guidelines for acute upper respiratory tract infection in children [J]. China Journal of Chinese Materia Medica, 2017, 42 (8): 1510 (in Chinese).

    [4] YIN M S, ZHANG Y C, XU S H, et al. Puerarin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of inflammation [J]. J Asian Nat Prod Res, 2019, 21 (5): 476.

    [5] DAVID M, ALESSANDRO L, JENNIFER T, et al. Preferred reporting items for systematic reviews and Meta-analyses: the PRISMA statement [J]. J Clin Epidemiol, 2009, 62 (10): 12.

    [6] LI E, CHEN G T, YE Z M, et al. Integrated Clinical Encyclopedia of Traditional and Western Medicine [M]. Beijing: Tcm Classics Publishing House, 1996 (in Chinese).

    [7] National Administration of Traditional Chinese Medicine. Criteria for diagnosis and efficacy of traditional Chinese Medicine [M]. Nanjing: Nanjing University Press, 1994 (in Chinese).

    [8] WANG L, DONG X. Effect of Ganmao Qingre Granule on TCM syndrome score of children with wind-cold [J]. China Medical Devices, 2017, 32 (S2): 85 (in Chinese).

    [9] DI J H. Clinical observation of Ganmao Qingre Granule in the treatment of 30 children with wind- cold [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2012, 4 (3): 277 (in Chinese).

    [10] HUANG Y. Clinical observation of Ganmao Qingre Granule in the treatment of 37 children with wind- cold [C]. Zhuhai: The founding meeting of digital Chinese medicine branch of International Digital Medical Association and the first digital Chinese medicine academic exchange meeting, 2016 (in Chinese).

    [11] YANG M J, WEI Y L, HOU Y Y, et al. Clinical observation of Ganmao Qingre Granule in the treatment of 37 children with wind- cold [J]. Guide of China Medicine, 2015, 13 (22): 192 (in Chinese).

    [12] LIU C. Observation on curative effect of Ganmao Qingre Granule on 160 cases of children with wind-cold [J]. Modern Medicine and Health Research Electronic Journal, 2018, 2 (7): 175 (in Chinese).

    [13] BANG D H, WANG L Y. Analysis of the curative effect of Ganmao Qingre Granule in the treatment of children with wind-cold [J]. Chinese Medicine Modern Distance Education of China, 2016, 14 (6): 95 (in Chinese).

    [14] RONG P, MA R, LIU Q H, et al. A commentary of literature research of TCM for acute upper respiratory tract infection in children [J]. China Journal of Chinese Materia Medica, 2017, 42 (8): 1455 (in Chinese).

    [15] LIU C M. Treatment of viral cold in children [J]. Seek Medical and Ask the Medicine, 2012, 10 (7): 566 (in Chinese).

    [16] LU Q, AN S H, AI T, et al. Expert consensus on standardized diagnosis and treatment of common cold in children in China (2013) [J]. Chinese Journal of Practical Pediatrics, 2013, 28 (9): 680 (in Chinese).

    [17] YUAN Y D, LIU T T, LIU Y X, et al. Optimization of randomized methods for clinical trials [J]. Chinese Journal of Health Statistics, 2019, 36 (2): 204 (in Chinese).

    [18] ZHANG Y, JIA L Y, SHAO J Z, et al. Principles, problems and evaluation of blind method in clinical research of traditional Chinese Medicine [J]. Beijing Journal of Traditional Chinese Medicine, 2018, 37 (12): 1159 (in Chinese).

    [19] YU D D, XIE Y M, ZHANG Y L, et al. Systematic review and Meta-analysis on randomized controlled trials on effectiveness and safety of Kudiezi Injection in treatment of acute cerebral infarction [J]. China Journal of Chinese Materia Medica, 2019, 44 (2): 372 (in Chinese).

    [20] 中医药与中西医结合临床研究方法指南 [J]. Chinese Journal of Integrated Traditional and Western Medicine, 2015, 35 (8): 901 (in Chinese).

    [21] WANG Y. Introduction of Cochrane bias risk assessment tool [J]. Chinese General Practice, 2019, 22 (11): 1322 (in Chinese).

    [22] HUANG P. Pharmacodynamics and pharmacokinetics of Qingre granules [D]. Jinan: Shandong University of Traditional Chinese Medicine, 2013 (in Chinese).

    [23] HIGGINS J, GREEN S E. Cochrane handbook for systematic reviews of interventions version 5.1.0. the cochrane collaboration (Eds) [J]. N-S Arch Pharmacol, 2011, 5 (2): S38.

    [24] WANG W, CHANG Z, GU Y R, et al. Meta analysis of treating positive-ACA recurrent spontaneous abortion by the method of invigorating-kidney and promoting blood-circulation [J] . Western Journal of Traditional Chinese Medicine, 2019, 32 (4): 81 (in Chinese).

This Article

ISSN:1001-5302

CN: 11-2272/R

Vol 45, No. 14, Pages 3292-3298

July 2020

Downloads:0

Share
Article Outline

Knowledge

Abstract

  • 1 Materials and methods
  • 2 Results
  • 3 Discussion
  • 4 Conclusion
  • References