Study on chemical constituents from Mastic (Pistacia lentiscus)
(2.Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, Xinjiang, China 830011)
(3.Department of Pathology, Armed Police Corps Hospital of Xinjiang, Urumqi, Xinjiang, China 830000)
(4.College of Life Science, Jiangxi Normal University, Nanchang, Jiangxi, China 330022)
【Abstract】Phytochemical investigation on the methanol extract of Mastic (Pistacia lentiscus) by using various chromatographic techniques led to the isolation of nine compounds. Based on the analysis of spectroscopic data (NMR and MS) and/or comparisons with the data reported in the literature, their structures were elucidated as 3β,8α,13-trihydroxypolypoda-14-methoxy-14-methyl-17,21-diene (1), 4-hydroxymyrtenal (2), 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol (3), 2-oxo-Δ3-4,5,5-trimethylcyclopentynyl acidic acid (4), (1S,2R,3R,5R)-6,6-dimethyl-4-methylidenebicyclo[3.1.1]-heptane-2,3-diol (5), (4R)-1-methyl-4-(1-hydroxyisopropyl)cyclohexene-6-one (6), 6,6-dimethyl-4-hydroxy[3.1.1]hept-2-ene-2-carboxylic acid (7), 6,6-dimethyl[3.1.1]hept-2-ene-2-carboxylic acid (8), 6,6-dimethyl-4-oxobicyclo[3.1.1]hept-2-ene-2-carboxylic acid (9). Compound 1 was a new compound and compounds 2-9 were isolated from this species for the first time. In vitro cytotoxicity assay results indicated that compounds 1, 6 and 7 showed significant inhibitory effects against human lung cancer cell line A549 with IC50 values of 20.4, 25.1 and 22.5 μmoL·L−1.
【Keywords】 Mastic; chemical constituents; terpenoids; cytotoxicities;
(Translated by FU LJ)
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