Network Meta-analysis of oral Chinese patent medicine in treatment of acute cerebral infarction

CUI Rui-zhao1 YU Dan-dan1 LI Hui-min1 HU Rui-xue1 ZHAO Hui2 LIAO Xing1

(1.Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China 100700)
(2.China Center for Evidence Based Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China 100700)

【Abstract】The efficacy of oral Chinese patent medicine in the treatment of acute cerebral infarction was systematically evaluated by network Meta-analysis. The literature search was conducted in three English databases (Medline, EMbase and Cochrane Library) and four Chinese databases (CNKI, VIP, WanFang and SinoMed) from inception to June 2018, and the randomized controlled trials of acute cerebral infarction were screened out according to the pre-set criteria. Two reviewers independently screened out the literature by using pre-specified eligibility criteria, and assessed the quality of included studies according to the risk of bias tool of Cochrane Handbook 5.1.0. Data analysis was conducted by using Stata 13.0 and WinBUGS 1.4.3 software. Finally, 52 RCTs were included with 11 oral Chinese patent medicines involved. The results of the network Meta-analysis showed that in terms of the total effective rate, the order of efficacy was as follows: Naomaitai Capsules > Xiaoshuan Changrong Capsules > Angong Niuhuang Pills > Yangxue Qingnao Granules > Compound Danshen Dripping Pills > Naoxintong Capsules > Tongxinluo Capsules > Naoxueshu Oral Liquid > Zhuyu Tongmai Capsules > Yinxingye Tablets > Compound Danshen Tablets; in terms of neurological deficit scores, the order of efficacy was as follows: Tongxinluo Capsules > Angong Niuhuang Pills > Compound Danshen Dripping Pills > Xiaoshuan Changrong Capsules > Yangxue Qingnao Granules > Zhuyu Tongmai Capsules > Naoxintong Capsules > Naoxueshu Oral Liquid; in terms of Barthel index score, the order of efficacy was as follows: Xiaoshuan Changrong Capsules > Naomaitai Capsules > Naoxueshu Oral Liquid > Angong Niuhuang Pills > Tongxinluo Capsules > Zhuyu Tongmai Capsules. Although different oral Chinese patent medicines can improve these outcomes, the difference in efficacy ranking was relatively large. Because of the small number and low quality of research literature, the conclusion still needs to be proved by multi-center, large-sample, and double-blind randomized trials.

【Keywords】 Chinese patent medicine; acute cerebral infarction; network Meta-analysis;

【DOI】

【Funds】 General Program of the National Natural Science Foundation of China (81774159) Fundamental Scientific Research Funding Project of China Academy of Chinese Medical Sciences for Special Training Program of Outstanding Young Scientific and Technological Talents (Innovation) (ZZ13-YQ-075) Self-selected Project of the Central Public-interest Scientific Institution Basal Research Fund (Thirteenth Batch, Z0650) 2019 Evidence-based Medicine Research Project of Traditional Chinese Medicine of China Academy of Chinese Medical Sciences (ZZ13-024-3)

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(Translated by SU JB)

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This Article

ISSN:1001-5302

CN:11-2272/R

Vol 45, No. 11, Pages 2642-2657

June 2020

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Article Outline

Abstract

  • 1 Materials and methods
  • 2 Results
  • 3 Discussion
  • References