Clinical efficacy of Matrine and Sodium Chloride Injection in treatment of 40 cases of COVID-19

YANG Ming-wei1 CHEN Feng2 ZHU Ding-jun2 LI Jia-zhu2 ZHU Jin-ling2 ZENG Wei2 QU Shi-lin2 ZHANG Yun2

(1.Jingmen 2nd People’s Hospital of Hubei Province, Jingmen 448000)
(2.Jingzhou Hospital of Infectious Disease (Chest Hospital) of Hubei Province, Jingzhou 434000)

【Abstract】In this paper, we analyzed medical records of 40 patients with coronavirus disease 2019 (COVID-19), in order to explore the clinical efficacy of Matrine and Sodium Chloride Injection in the treatment of COVID-19. The investigation was based on the results of a previous animal test, which was aimed to investigate and confirm the clinical efficacy of Matrine and Sodium Chloride Injection in the treatment of COVID-19. The animal test demonstrated that Matrine and Sodium Chloride Injection had a significant therapeutic effect on the human coronavirus-induced pneumonia for the model mice. The lung inhibition index reached up to 86.86%. The evaluation was conducted on 40 confirmed cases of COVID-19 treated at Jingzhou Hospital of Infectious Disease (Chest Hospital) of Hubei Province from January 30 to March 21, 2020. In these cases, patients were treated with other integrated Chinese and Western medicines regimens in the recommended Matrine and Sodium Chloride Injection diagnosis and treatment regimen. The clinical manifestations, laboratory data, nucleic acid clearance time, and imaging data were compared and analyzed before and after treatment. After administration with Matrine and Sodium Chloride Injection, the clinical symptoms of 40 cases were alleviated markedly, and their blood analysis and biochemical indices returned to normal. The lung CT showed more than 50% of the lesion absorption rate. The viral nucleic acid test showed the average clearance time of patients was 16.6 days, and the average length of hospital stay was 25.9 days. After administration with Matrine and Sodium Chloride Injection, the symptoms of cough and fatigue were alleviated significantly, and the appetite was significantly improved compared with before, especially for patients with gastrointestinal symptoms. Additionally, the laboratory indices, especially absolute value and ratio of lymphocytes and CRP were significantly alleviated. According to the chest CT for short-term review, the absorption of lung lesions was faster than before, especially for grid-like and fibrotic lesions. Compared with antiviral drugs, such as Arbidol and Kaletra, the nucleic acid clearance time was significantly shorter than that of the cases treated with Matrine and Sodium Chloride Injection. The clinical effective rate of 40 cases was 100.0%. We believe that Matrine and Sodium Chloride Injection has a good clinical effect in the treatment of COVID-19 and suggest increasing the clinical application and further conducting large-sample-size clinical verification.

【Keywords】 coronavirus disease 2019 (COVID-19); clinical efficacy; Matrine and Sodium Chloride Injection;

【DOI】

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(Translated by ZHAO B)

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This Article

ISSN:1001-5302

CN:11-2272/R

Vol 45, No. 10, Pages 2221-2231

May 2020

Downloads:14

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Article Outline

Abstract

  • 1 Data and methods
  • 2 Results
  • 3 Discussion
  • References