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Preliminary investigation on processing mechanism of Radix Euphorbiae Kansui by Radix Glycyrrhizae based on thermal analysis technology

HE Mei-jing1 LV Chen-zi1 WANG Bo1 MENG Xiang-long2,3 ZHANG Shuo-sheng2

(1.Institute of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong, China 030619)
(2.Institute of Pharmaceutical and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong, China 030619)
(3.Department of Herbology, College of Oriental Medicine, Dongguk University, Gyeongju 780-714, Korea )

【Abstract】In the thermal analysis, the pyrolysis characteristics of unprocessed Radix Euphorbiae Kansui, alcohol extract of Radix Euphorbiae Kansui, petroleum ether fraction, chloroform fraction, ethyl acetate fraction, n-butanol alcohol fraction, and Radix Glycyrrhizae vinegar were analyzed with simulated air (N2-O2 4:1) as the carrier gas, at the temperature increasing rate of 10 °C·min−1, and the volume flow rate of 60 mL·min−1, respectively. The results showed that due to the different polarity of the extraction solvent, the type and quantity of the chemical components contained in each polar part were different, and with the increase in the amount of solid powder of Radix Glycyrrhizae, the peak of the maximum heat loss rate was achieved in advance. The peak of the maximum heat loss rate of petroleum ether, chloroform, and ethyl acetate fractions was achieved (157.40 ± 1.06) °C, 3.50 °C, (25.83 ± 1.66) °C in advance, respectively, but the weight-loss rate of the chloroform fraction was increased by (2.62 ± 5.19) °C, while decreased by (33.90 ± 1.72) °C and (19.28 ± 1.11) °C for the petroleum ether and ethyl acetate fractions. Therefore, we can conclude that with the addition of Radix Glycyrrhizae, the pyrolysis rate of the petroleum ether and chloroform fractions in the toxic part of Radix Euphorbiae Kansui was increased; the temperature point at the peak of the maximum weight-loss rate was decreased, and the ethyl acetate fraction (effective part) showed a decreasing trend with the increase of temperature, but its overall ratio of weight loss and weight-loss rate were relatively small, retaining the effect of medicinal ingredients. This proved the mechanism of Radix Glycyrrhizae on attenuating the toxicity of Radix Euphorbiae Kansui after processing and the scientificity and rationality of Radix Glycyrrhizae in processing Radix Euphorbiae Kansui. At the same time, as the proportion of glycyrrhizin was increased and the peak of the maximum heat loss rate of petroleum ether, chloroform and ethyl acetate fractions occurred in advance; the peak temperature was decreased, with easy pyrolysis. Among them, the thermogravimetric rate of the mixture of petroleum ether and chloroform fractions (10:1) was relatively large, with a low peak temperature, while ethyl acetate fraction showed the opposite result. This conclusion has certain guiding significance for the ratio of Radix Euphorbiae Kansui to Radix Glycyrrhizae.

【Keywords】 Radix Euphorbiae Kansui; thermal analysis; processing mechanism;

【DOI】

【Funds】 General Project of National Natural Science Foundation of China (81673601) Key Research and Development Program of Shanxi Province (201603D3112002)

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This Article

ISSN:1001-5302

CN: 11-2272/R

Vol 43, No. 21, Pages 4255-4263

November 2018

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Article Outline

Abstract

  • 1 Materials
  • 2 Methods
  • 3 Results
  • 4 Discussion
  • References