Studies on chemical constituents of Clerodendrum bungei

ZHANG Gui-jie1 DAI Lu-mei2 ZHANG Bin2 ZHANG Yong-li1 WANG Heng-shan2 LIANG Dong2

(1.College of Pharmacy, Guilin Medical University, Guilin, Guangxi Province, China 541004)
(2.State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, Guangxi Province, China 541004)

【Abstract】Ten compounds were isolated from the 95% aqueous EtOH extract of Clerodendrum bungei by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, MCI, ODS, and semi-preparative HPLC. Their structures were elucidated as 11, 12, 16S-trihydroxy-7-oxo-17 (15 →16), 18 (4 →3)-diabeo-abieta-3, 8, 11, 13-tetraen-18-oic acid (1), 12S*, 13R*-dihydroxy-9-oxo-octadeca-10 (E)-enoic acid (2), clerodenoside A (3), trichotomoside (4), glycosmisic acid (5), 4'-O-methylscutellarein (6), neroplomacrol (7), butylitaconic acid (8), hexylitaconic acid (9), p-hydroxybenzonic acid (10) by their physicochemical properties and spectroscopic data. Compounds 1 and 2 were new natural products, while compounds 7–10 were obtained from the genus Clerodendrum for the first time, and compounds 3, 5, 6 were isolated from this plant for the first time.

【Keywords】 Clerodendrum bungei Steud.; Verbenaceae; chemical constituents; diterpenoids;

【DOI】

【Funds】 Natural Science Foundation of China (21562017) Natural Science Foundation of Guangxi Province, China (2014GXNSFBA118189)

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(Translated by SONG JF)

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This Article

ISSN:1001-5302

CN: 11-2272/R

Vol 42, No. 24, Pages 4788-4793

December 2017

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Article Outline

Abstract

  • 1 Materials
  • 2 Extraction and separation
  • 3 Structural identification
  • References