Study on chemical constituents of Codonopsis pilosula
(2.College of Pharmacy, North China University of Science and Technology, Tangshan, China 063000)
【Abstract】A new neolignan, (−)-(7R, 8S, 7'E)-3', 4-dihydroxy-3-methoxy-8, 4'-oxyneoligna-7'-ene-7, 9, 9'-triol (1), and seven known compounds, 9-(tetrahydropyran-2-yl)-nona-trans, trans-2, 8-diene-4, 6-diyn-1-ol (2), 9-(tetrahydropyran-2-yl)-trans-non-8-ene-4, 6-diyn-1-ol (3), lobetyol (4), lobetyolin(5), dehydrodieoniferyl alcohol (6), 5-hydroxymethylfurfural (7), and 4, 4'-dihydroxy-3, 3'-dimethoxy-trans-stilbene (8), were isolated from the H2O extract of Codonopsis pilosula. The structures of 1-8 were elucidated by spectroscopic methods including NMR, HR-ESI-MS, and CD. In addition, compounds 2 and 3 were isolated from the genus Codonopsis for the first time.
【Keywords】 Codonopsis pilosula; Campanulaceae; chemical constituent; neolignan; Codonopsis pilosula; Campanulaceae; chemical constituent; neolignan;
Wang J, Deng C Q, Shi L, et al. Guide of China Medicine, 2011, 31(9): 279 (in Chinese).
Cai D G. Advances and Goal in the Study of Chemical Constituents of Dangshen[J]. China Journal of Chinese Materia Medica, 1991, 16(6): 376 (in Chinese).
Feng P P, Li Z X, Yuan Z. Review on the phytochemical and pharmacological study of Codonopsis Genus[J]. Journal of Shenyang Pharmaceutical University, 2012, 29(4): 307–311 (in Chinese).
Chen K K. Research Progress in Codonopisis pilosula[J]. Journal of Xi' an University of Arts & Science(Natural Science Edition), 2008, 11(2): 33–39 (in Chinese).
Wang J Z, Wang F P. Studies ON THE CHEMICAL CONSTITUENTS OF CODONOPSIS TANGSHEN OLIV. [J]. Natural Product Research and Development, 1996, 8(2): 8–12 (in Chinese).
Song D, Wang Z T, Li L Y, et al. Protective Effect of Lobetyolin on Gastric Mucosa of Experimental Gastric Ulcer in Rats[J]. Journal of Emergency in Traditional Chinese Medicine, 2008, 17(7): 963 (in Chinese).
Wang Z T, Xu G J, Masao Hattori, et al. HPLC Analysis of Atractylenolide Ⅲ in the Roots of Codonopsis Plants[J]. Journal of China Pharmaceutical University, 1992, 23(1): 48–50 (in Chinese).
Zhang M, Dong X P. A new sesqui-norlignan from Herpetospermum pedunculosum[J]. Acta Pharmaceutica Sinica, 2006, 41(7): 659–661 (in Chinese).
Lu D, Liu J P, Zhao Y Z, et al. Chinese Traditional and Herbal Drugs, 2010, 41(5): 700 (in Chinese).