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冯亚静1 王晓霞2 庄鹏宇2 张丹阳2 高磊2 陈金铭1 韩刚2

(1.华北理工大学公共卫生学院, 河北唐山 063000)
(2.华北理工大学药学院, 河北唐山 063000)


【关键词】 党参;桔梗科;化学成分;新木脂素;


【基金资助】 河北省自然科学基金项目(H2014209214,H2015209094);

Study on chemical constituents of Codonopsis pilosula

FENG Ya-jing1 WANG Xiao-xia2 ZHUANG Peng-yu2 ZHANG Dan-yang2 GAO Lei2 CHEN Jin-ming1 HAN Gang2

(1.School of Public Health, North China University of Science and Technology, Tangshan, China 063000)
(2.College of Pharmacy, North China University of Science and Technology, Tangshan, China 063000)

【Abstract】A new neolignan, (−)-(7R, 8S, 7'E)-3', 4-dihydroxy-3-methoxy-8, 4'-oxyneoligna-7'-ene-7, 9, 9'-triol (1), and seven known compounds, 9-(tetrahydropyran-2-yl)-nona-trans, trans-2, 8-diene-4, 6-diyn-1-ol (2), 9-(tetrahydropyran-2-yl)-trans-non-8-ene-4, 6-diyn-1-ol (3), lobetyol (4), lobetyolin(5), dehydrodieoniferyl alcohol (6), 5-hydroxymethylfurfural (7), and 4, 4'-dihydroxy-3, 3'-dimethoxy-trans-stilbene (8), were isolated from the H2O extract of Codonopsis pilosula. The structures of 1-8 were elucidated by spectroscopic methods including NMR, HR-ESI-MS, and CD. In addition, compounds 2 and 3 were isolated from the genus Codonopsis for the first time.

【Keywords】 Codonopsis pilosula; Campanulaceae; chemical constituent; neolignan;


【Funds】 Natural Science Foundation of Hebei Province (H2014209214, H2015209094);

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This Article


CN: 11-2272/R

Vol 42, No. 01, Pages 135-139

January 2017


Article Outline


  • 1 Materials
  • 2 Isolation and extraction
  • 3 Structural identification
  • References