Study on chemical constituents of Codonopsis pilosula
(2.College of Pharmacy, North China University of Science and Technology, Tangshan, China 063000)
【Abstract】A new neolignan, (−)-(7R, 8S, 7'E)-3', 4-dihydroxy-3-methoxy-8, 4'-oxyneoligna-7'-ene-7, 9, 9'-triol (1), and seven known compounds, 9-(tetrahydropyran-2-yl)-nona-trans, trans-2, 8-diene-4, 6-diyn-1-ol (2), 9-(tetrahydropyran-2-yl)-trans-non-8-ene-4, 6-diyn-1-ol (3), lobetyol (4), lobetyolin(5), dehydrodieoniferyl alcohol (6), 5-hydroxymethylfurfural (7), and 4, 4'-dihydroxy-3, 3'-dimethoxy-trans-stilbene (8), were isolated from the H2O extract of Codonopsis pilosula. The structures of 1-8 were elucidated by spectroscopic methods including NMR, HR-ESI-MS, and CD. In addition, compounds 2 and 3 were isolated from the genus Codonopsis for the first time.
【Keywords】 Codonopsis pilosula; Campanulaceae; chemical constituent; neolignan;
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