Study on chemical constituents of Codonopsis pilosula

FENG Ya-jing1 WANG Xiao-xia2 ZHUANG Peng-yu2 ZHANG Dan-yang2 GAO Lei2 CHEN Jin-ming1 HAN Gang2

(1.School of Public Health, North China University of Science and Technology, Tangshan, China 063000)
(2.College of Pharmacy, North China University of Science and Technology, Tangshan, China 063000)

【Abstract】A new neolignan, (−)-(7R, 8S, 7'E)-3', 4-dihydroxy-3-methoxy-8, 4'-oxyneoligna-7'-ene-7, 9, 9'-triol (1), and seven known compounds, 9-(tetrahydropyran-2-yl)-nona-trans, trans-2, 8-diene-4, 6-diyn-1-ol (2), 9-(tetrahydropyran-2-yl)-trans-non-8-ene-4, 6-diyn-1-ol (3), lobetyol (4), lobetyolin(5), dehydrodieoniferyl alcohol (6), 5-hydroxymethylfurfural (7), and 4, 4'-dihydroxy-3, 3'-dimethoxy-trans-stilbene (8), were isolated from the H2O extract of Codonopsis pilosula. The structures of 1-8 were elucidated by spectroscopic methods including NMR, HR-ESI-MS, and CD. In addition, compounds 2 and 3 were isolated from the genus Codonopsis for the first time.

【Keywords】 Codonopsis pilosula; Campanulaceae; chemical constituent; neolignan;

【DOI】

【Funds】 Natural Science Foundation of Hebei Province (H2014209214, H2015209094)

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    References

    [1]Wang J, Deng C Q, Shi L, et al. Guide of China Medicine, 2011, 31(9): 279 (in Chinese).

    [2]Cai D G. Advances and Goal in the Study of Chemical Constituents of Dangshen[J]. China Journal of Chinese Materia Medica, 1991, 16(6): 376 (in Chinese).

    [3]Feng P P, Li Z X, Yuan Z. Review on the phytochemical and pharmacological study of Codonopsis Genus[J]. Journal of Shenyang Pharmaceutical University, 2012, 29(4): 307–311 (in Chinese).

    [4]Chen K K. Research Progress in Codonopisis pilosula[J]. Journal of Xi' an University of Arts & Science(Natural Science Edition), 2008, 11(2): 33–39 (in Chinese).

    [5]Wang J Z, Wang F P. Studies ON THE CHEMICAL CONSTITUENTS OF CODONOPSIS TANGSHEN OLIV. [J]. Natural Product Research and Development, 1996, 8(2): 8–12 (in Chinese).

    [6]Song D, Wang Z T, Li L Y, et al. Protective Effect of Lobetyolin on Gastric Mucosa of Experimental Gastric Ulcer in Rats[J]. Journal of Emergency in Traditional Chinese Medicine, 2008, 17(7): 963 (in Chinese).

    [8]Wang Z T, Xu G J, Masao Hattori, et al. HPLC Analysis of Atractylenolide Ⅲ in the Roots of Codonopsis Plants[J]. Journal of China Pharmaceutical University, 1992, 23(1): 48–50 (in Chinese).

    [15]Zhang M, Dong X P. A new sesqui-norlignan from Herpetospermum pedunculosum[J]. Acta Pharmaceutica Sinica, 2006, 41(7): 659–661 (in Chinese).

    [16]Lu D, Liu J P, Zhao Y Z, et al. Chinese Traditional and Herbal Drugs, 2010, 41(5): 700 (in Chinese).

This Article

ISSN:1001-5302

CN: 11-2272/R

Vol 42, No. 01, Pages 135-139

January 2017

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Article Outline

Abstract

  • 1 Materials
  • 2 Isolation and extraction
  • 3 Structural identification
  • References