Preliminary research on effect of licorice-processed Tripterygium wilfordii on reducing liver toxicity

ZHAO Xiao-mei1 GONG Man2 DONG Jie-ming1 WANG Jia-bo3 XIAO Xiao-he2 ZHAO Kui-jun1 MA Zhi-jie1,3

(1.Beijing Friendship Hospital, Capital Medical University, Beijing, China 100050)
(2.Integrative Medicine Center for Liver Disease Diagnosis and Treatment, 302 Military Hospital of China, Beijing, China 100039)
(3.China Military Institute of Chinese Medicine, 302 Military Hospital of China, Beijing, China 100039)

【Abstract】To explore the effect of the licorice-processed Tripterygium wilfordii on reducing the liver toxicity. In animal experiments, the liver toxicity of T. wilfordii was evaluated both before and after processing, and the differences in liver tissue biopsy, serum biochemical indexes and inflammatory cell factor among blank group, T. wilfordii group and licorice-processed T. wilfordii group were observed. Liver tissue biopsy results showed that liver tissue injury was obvious in T. wilfordii group, and no obvious injury was found in licorice-processed T. wilfordii group. As compared with the blank group, the levels of AST, ALT and CRE were significantly increased (P < 0.01), UREA was increased (P < 0.05), and ALB level was significantly decreased (P < 0.01) in the T. wilfordii group. As compared with T. wilfordii group, the levels of AST, ALT, CRE, and UREA were decreased (P < 0.01), while ALB was increased (P < 0.01) in the licorice-processed T. wilfordii group. The results of inflammatory factors in rats showed that the levels of IL-1β, IL-6, and TNF-α in T. wilfordii group were significantly higher than those in blank group (P < 0.01); the levels of IL-1β, IL-6, and TNF-α in licorice-processed T. wilfordii group were significantly lower than those in T. wilfordii group (P < 0.01). Overall, licorice processing of T. wilfordii can effectively reduce the liver toxicity and reduce the liver injury caused by T. wilfordii. The experiment can provide reference for the clinical rational use of the T. wilfordii, and provide data support for the studies on reducing the liver toxicity of T. wilfordii by licorice processing.

【Keywords】 Tripterygium wilfordii; licorice; processing attenuated; liver toxicity; inflammatory factor;

【DOI】

【Funds】 Fund Project of Beijing Municipal Administration of Traditional Chinese Medicine (QN2014-18) Special Project of Beijing University of Chinese Medicines (15ZY04) Initiation Project of Beijing Friendship Hospital (YYQDKT2014-20) “Young Crop” Talents Training Plan Project of Beijing Municipal Administration of Hospitals (QML20160106) Program of the Capital Health Research and Development (2016-4-2024)

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(Translated by SONG Junfeng)

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This Article

ISSN:1001-5302

CN: 11-2272/R

Vol 42, No. 01, Pages 119-124

January 2017

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Article Outline

Abstract

  • 1 Materials
  • 2 Methods
  • 3 Results
  • 4 Conclusions
  • References