山茱萸的化学成分研究
(2.中日友好医院临床医学研究所, 北京 100029)
(3.中日友好医院药学部, 北京 100029)
(4.河南大学药物研究所, 河南开封 475004)
(5.首都医科大学附属北京世纪坛医院药剂科, 北京 100038)
(6.北京中医药大学基础医学院, 北京 100029)
(7.免疫炎性疾病北京市重点实验室, 北京 100029)
【摘要】利用各种色谱技术对山茱萸的化学成分进行研究,从山茱萸水提取物中分离得到6个化合物,分别为6'-O-乙酰基7α-O-乙基莫诺苷(1),(-)-isolariciresinol 3α-O-β-D-glucopyranoside(2),芹菜素(3),cirsiumaldehyde(4),对香豆酸(5),咖啡酸(6),其中化合物1为新化合物,化合物2~4为首次从山茱萸属植物中分离得到。利用MTT法检测了化合物2~6对缺氧缺糖损伤的PC12细胞的保护作用,结果表明化合物4在1.0μmol·L-1的浓度下,对OGD/R损伤的PC12细胞物有一定的保护作用。
【关键词】 山茱萸; 化学成分; 6'-O-乙酰基-7α-O-乙基莫诺苷; PC12细胞;
【DOI】
【基金资助】
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References
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ISSN:1001-5302
CN: 11-2272/R
Vol 41, No. 24, Pages 4605-4609
December 2016
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