Chemical constituents from ripe fruit of Cornus officinalis
(2.Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China 100029)
(3.Department of Pharmacy, China-Japan Friendship Hospital, Beijing, China 100029)
(4.Pharmaceutical Institute, Henan University, Kaifeng, China 475004)
(5.Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China 100038)
(6.School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing, China 100029)
(7.Beijing Key Laboratory for Immune-Mediated Inflammatory Diseases, Beijing, China 100029)
【Abstract】To investigate the chemical compounds from the fruit of Cornus officinalis, six compounds were isolated and determined by extensive spectroscopic analysis as 6'-O-acetyl-7α-O-ethyl morroniside (1), (−)-isolariciresinol 3α-O-β-D-glucopyranoside (2), apigenin (3), cirsiumaldehyde (4), p-coumaric acid (5), caffeic acid (6). Compound 1 was a new iridoid glucoside, and compounds 2–4 were obtained from the Cornus genus for the first time. Compounds 2–6 were evaluated for the viability of PC12 cells when exposed in conditions of oxygen and glucose deprivation. The MTT results showed that compound 4 increased cell viability moderately in OGD/R treated PC12 cells at concentration of 1.0 μmol·L−1.
【Keywords】 Cornus officinalis; chemical constituents; 6'-O-acetyl-7α-O-ethyl morroniside; PC12 cells;
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