Chemical constituents from ripe fruit of Cornus officinalis

YE Xian-sheng1,2 HE Jun3 ZHANG Jia-lin4 PANG Xiao-bin4 ZHANG Lei5 QIAO Hao-yi6 PAN Xue-ge6 ZHANG Jia1 LIU Shu-na1 ZHANG Wei-ku2,7 XU Jie-kun6

(1.School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China 100029)
(2.Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China 100029)
(3.Department of Pharmacy, China-Japan Friendship Hospital, Beijing, China 100029)
(4.Pharmaceutical Institute, Henan University, Kaifeng, China 475004)
(5.Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China 100038)
(6.School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing, China 100029)
(7.Beijing Key Laboratory for Immune-Mediated Inflammatory Diseases, Beijing, China 100029)

【Abstract】To investigate the chemical compounds from the fruit of Cornus officinalis, six compounds were isolated and determined by extensive spectroscopic analysis as 6'-O-acetyl-7α-O-ethyl morroniside (1), (−)-isolariciresinol 3α-O-β-D-glucopyranoside (2), apigenin (3), cirsiumaldehyde (4), p-coumaric acid (5), caffeic acid (6). Compound 1 was a new iridoid glucoside, and compounds 24 were obtained from the Cornus genus for the first time. Compounds 26 were evaluated for the viability of PC12 cells when exposed in conditions of oxygen and glucose deprivation. The MTT results showed that compound 4 increased cell viability moderately in OGD/R treated PC12 cells at concentration of 1.0 μmol·L−1.

【Keywords】 Cornus officinalis; chemical constituents; 6'-O-acetyl-7α-O-ethyl morroniside; PC12 cells;

【DOI】

【Funds】 National Natural Science Foundation of China (81473119, 81473590, 81402814, 81274115) Yong Talent Project in Science and Technology of China-Japan Friendship Hospital (2014-QNYC-B-10)

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This Article

ISSN:1001-5302

CN: 11-2272/R

Vol 41, No. 24, Pages 4605-4609

December 2016

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Article Outline

Abstract

  • 1 Materials
  • 2 Extraction and isolation
  • 3 Structure identification
  • 4 Protection effect of compounds towards OGD/R treated PC12 cell
  • References