Meta-analysis on effect of compound Danshen injection in treating neonatal hypoxic-ischemic encephalopathy

HUANG Xiong-feng1 WANG Jian-min1 CHEN Qiao1 WEI Yan-yan1 CHEN Hong-wei1

(1.Jiangxi University of Traditional Chinese Medicine, Nanchang, China 330004)
【Knowledge Link】the central nervous system

【Abstract】To systematically evaluate the clinical efficacy and safety of compound Danshen injection in treating hypoxic-ischemic encephalopathy ( HIE) of newborns. Computer retrievals were made in PubMed, Embase, Cochrane Library, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), VIP and Chinainfo ( before May 2014) and relevant literature references, and manual retrievals were made for journals and conference papers, in order to collect randomized or semi-randomized controlled trials concerning compound Danshen injection in the treatment of neonatal HIE. The quality of included references was evaluated according to literatures recommended by Cochrane Handbook. RevMan 5.3 software was applied in the statistical treatment. Finally, a total of 13 randomized controlled trials were included, covering 1211 patients (including 639 patients in the compound Danshen injection-treated group and 572 patients in the control group). Meta-analysis results showed that the routine treatment combined with compound Danshen injection can improve the treatment efficiency of neonatal HIE [RR = 1.28; 95% CI (1.21–1.36)], reduce the mortality rate [RR = 0.42; 95% CI ( 0.23–0.75)]and the incidence of long-term neurological sequelae [RR = 0.48; 95% CI (0.35–0.65)], with statistical differences. No fatal side effect was observed in all of included trials. So far, limited evidences in this study proved that the application of compound Danshen injection in the treatment of neonatal HIE can enhance the clinical efficiency. However, because of the low quality of the included trials, more well-designed and large-scale multi-center randomized controlled trials shall be made in the future.

【Keywords】 compound Danshen injection; neonate; hypoxic-ischemic encephalopathy; Meta-analysis; evidence-based medicine;

【DOI】

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    References

    [1]Wang Caihua,Yao Liping,Han Yanbin,et al.Journal of Baotou Medical College,2010,26 (2):112.

    [2]Ma Bingxiang,Zhao Lina.Journal of Pediatrics of Traditional Chinese Medicine,2013,9 (3):45.

    [3]Higgins J P T,Green S.Cochrane handbook for systematic reviews of interventions version 5.1.0(2011-03)[M/OL].The Cochrane Collaboration,2011.http://www.cochrane-handbook.org.

    [4]Han Yukun.Journal of Pediatrics of Traditional Chinese Medicine,1997,35 (2 ):44.

    [5]Peters J L,Sutton A J,Jones D R,et al.Comparison of two methods to detect publication bias in meta-analysis[J].JAMA,2006,295 (6 ):676.

    [6]Higgins J P T,Thompson S G.Quantifying heterogeneity in a meta-analysis[J].Stat Med,2002,21 (11 ):1539.

    [7]Lin Xuejun.Aerospace Medicine,2010,21 (1 ):73.

    [8]Liu Guifen,Zhao Lintuan.Chinese Journal of Medicine,1999,34 (8 ):23.

    [9]Lian Weilin.Henan Journal of Practical Nervous Diseases,2000,3 (2 ):54.

    [10]Zhu Jianzheng,Cao Yunqiao.The Journal of Neonatology,1996,11 (1 ):29.

    [11]Zhou Shuicui.Zhejiang Journal of Integrated Traditional Chinese and Western Medicine,2000,10 (3 ):6 .

    [12]Yang Wei.Chinese Journal of Integrated Traditional and Western Medicine,2001,21 (11 ):6.

    [13]Gui Linyan,Wang Mingyan.Journal of Henan Medical College for Staff and Workers,2003,15 (4 ):59.

    [14]Cao Xiangye.Journal of Henan Practical Nervous Disease,2003,6 (4 ):81.

    [15]Li Xiaodong.Clinical Journal of Traditional Chinese Medicine,2005,17 (6 ):60.

    [16]Fu Zhaoyang,Jia Shouhui.Bulletin of Medical Research,2005,34 (4 ):77.

    [17]Jia Tailian,Zhu Fenglan,Wang Zheng.Journal of Applied Clinical Pediatrics,2004,19 (8 ):74.

    [18]Ding Zhonglian.Journal of Medical Forum,2007,28 (7 ):59.

    [19]Zhong Xinhua.Acta Academiae Medicinae Wannan,2005,23 (3 ):186.

    [20]Duan Tao,Chen Chao.National Medical Journal of China,2005,85 (17 ):1218.

    [21]Beilharz E J,Williams C E,Dragunow M,et al.Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat:evidence for apoptosis during selective neuronal loss[J].Mol Brain Res,1995,29 (1 ):1.

    [22]Nitatori T,Sato N,Waguri S,et al.Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis[J].J Neuro,1995,15(2):1001.

    [23]Han Wei,He Enxia,Cao Jingmei.China Journal of Chinese Materia Medica,2012,37(16):2498.

    [24]Wang Xinjie.Chinese Journal of Experimental Traditional Medical Formulae,2013,19(12):338.

    [25]Wang Lijing,Cui Yanling,Sun Limin,et al.China Modern Medicine,2011,18(7):74.

    [26]Vickers A,Goyal N,Harland R,et al.Do certain countries produce only positive results a systematic review of controlled trials [J].Contr Clin Trial,1998,19 (2 ):159.

    [27]Mueller K F,Meerpohl J J,Briel M,et al.Detecting,quantifying and adjusting for publication bias in meta-analyses:protocol of a systematic review on methods[J].Syst Rev,2013,2 (1 ):60.

    [28]Moher D,Pham B,Jones A,et al.Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses[J].Lancet,1998,352 (9128):609.

    [29]Bian Z,Liu B,Moher D,et al.Consolidated standards of reporting trials(CONSORT)for traditional Chinese medicine:current situation and future development[J].Front Med,2011,5 (2 ):171.

This Article

ISSN:1001-5302

CN: 11-2272/R

Vol 40, No. 01, Pages 141-148

January 2015

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Abstract

  • 1 Materials and Methods
  • 2 Results
  • 3 Discussion
  • References