Changing rules study of effective components of Glycyrrhizae Radix et Rhizoma before and after compatibilities in Sini decoction

PENG Wei1 JIANG Yan-ping1 FU Chao-mei1 GAO Fei2 YANG Huan1 LIU Ge-yi1 YU Jia-li1

(1.Pharmacy College, Chengdu University of Traditional Chinese Medicine; Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu, China 611137)
(2.Hong Kong University, Li Ka-shing Medical College; Traditional Chinese Medicine College, Hong Kong, China 999077)
【Knowledge Link】elute

【Abstract】The change of the effective components (liquiritin, glycyrrhizic acid, liquiritigenin, isoliquiritigenin) contents of Glycyrrhizae Radix et Rhizoma (GRR) before and after compatibilities in Sini decoction was studied in this paper. Taking single GRR decoction, GRR-Aconiti Lateralis Radix Praeparata (ALRP) decoction, GRR-Zingiberis Rhizoma (ZR) decoction and Sini decoction as test samples, the contents changing of the four effective components of GRR were measured by HPLC. The results showed that the contents of the four effective components of GRR in the single GRR decoction was higher than that in other samples, and the sequence was single GRR decoction > GRR-ZR decoction > GRR-ALRP decoction > Sini decoction. The contents of liquiritin were 11.18, 9.89, 9.67, 9.17 mg·g 1; the contents of glycyrrhizic acid were 20.76, 15.58, 11.30, 8.52 mg·g 1; the contents of liquiritigenin were 0.66, 0.57, 0.45, 0.24 mg·g 1; the contents of isoliquiritigenin were 0.14, 0.07, 0.03, 0.01 mg·g 1. Therefore, the effective components of GRR decreased obviously after GRR compatibility with ZR providing scientific basis for GRR relieving the strong nature of ZR. The effective components of GRR decreased sharply after GRR compatibility with ALRP providing scientific support for the ma-terial foundation research of GRR reducing the toxicity of ALRP. The effective components of GRR decreased further in Sini decoction indicating that the three medicines in Sini decoction were interactional, which reflecting the scientific connotation of the mutual-restraint/mutual-detoxication, mutual-promotion/mutual-assistance compatibilities in Sini decoction.

【Keywords】 Sini decoction; Glycyrrhizae Radix et Rhizoma; compatibility; content changing;

【DOI】

【Funds】 the National Natural Science Foundation of China (Grant No. 81373987)

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    References

    [1]Lei R E, Kang J.China Practical Medicine, 2012, 7(18): 193 (In Chinese).

    [2]Yu S F.Henan Traditional Chinese Medicine, 2014, 34(5 ): 801 (In Chinese).

    [3]Zhao X Q, Wang C G, Jiao H, et al.Chinese Journal of Gerontology, 2014, 34(3): 590 (In Chinese).

    [4]Ye Q, Guo Y P, Peng C, et al. Chinese Traditional Patent Medicine, 2013, 35 (5 ): 1035 (In Chinese).

    [5]Ma T S, Ge Y C, Jia Y H, et al. Liaoning Journal of Traditional Chinese Medicine, 2012, 39 (5): 948 (In Chinese).

    [6]Wang Z Q, Zeng R, Tan Z R, et al. Chinese Traditional Patent Medicine, 2012, 34 (12): 2305 (In Chinese).

    [7]Zhang J M, Li L, Gao F, et al. Acta Pharmaceutica Sinica, 2012, 47 (11): 1527 (In Chinese).

    [8]Zhang J M, Fu C M, He Y X, et al. Chinese Traditional and Herbal Drugs, 2013, 44 (2): 165 (In Chinese).

    [9]Chen Q W, Zhang J M, Ji N P, et al. Chinese Journal of Experimental Traditional Medical Formulae, 2014, 20 (2): 92 (In Chinese).

    [10]Li Y, Fu C M, Ren B, et al.China Journal of Chinese Materia Medica, 2014, 39 (16): 3166 (In Chinese).

    [11]Zhang J M,Liao W,He Y X,et al.Study on intestinal absorption and pharmacokinetic characterization of diester diterpenoid alkaloids in precipitation derived from Fuzi-Gancao herb-pair decoction for its potential interaction mechanism investigation[J].J Ethnopharmacol,2013,147 (1 ):128 .

    [12]Li Y, Zhang H M, He Y, et al. Chinese Traditional Patent Medicine, 2013, 35 (6): 1175 (In Chinese).

    [13]Feng Q R, Li B J, Yang X X. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease, 2014, 12 (2): 239 (In Chinese).

This Article

ISSN:1001-5302

CN: 11-2272/R

Vol 40, No. 01, Pages 84-88

January 2015

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Abstract

  • 1 Materials
  • 2 Methods
  • 3 Results and analysis
  • 4 Discussion
  • References