Controllability pyramid: an integrated control system of quality for traditional Chinese medicines

XIAO Xiao-he1 ZHANG Ding-kun1,2 WANG Jia-bo1 YANG Ming3 PENG Cheng2

(1.China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing, China 100039)
(2.Chengdu University of Traditional Chinese Medicine, Chengdu, China 611137)
(3.Jiangxi University of Traditional Chinese Medicine, Nanchang, China 330004)
【Knowledge Link】DNA

【Abstract】Quality control is one of the key scientific tissues in the modernization of traditional Chinese medicines (TCM). In order to overcome the deficiencies of assessment indexes, including little systematization and quantification, as well as loose association with clinical efficacy and dosage, a new integrated method named controllability pyramid (CP) is first proposed in this paper. In addition, some study cases are used to explain how this model is constructed. We hope the establishment of CP could promote the clinical-oriented integrated innovation research of TCM, and provide control strategy and technology examples for improving the quality of Chinese medicines and clinical efficacy.

【Keywords】 standardization of Chinese medicines; integrated control; controllability pyramid; effect-constituent index; integrated quality index;

【DOI】

【Funds】 the National Natural Science Foundation of China (Grant No.: 81274026) the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (Grant No.: 2011BAI13B05, 2012BAI09B02) the Special Funds of State Administration of Traditional Chinese Medicine (Grant No.: 201207002)

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    References

    [1] Xiao XH, Wang JB, Yan D, et al. Chinese Traditional and Herbal Drugs, 2012, 42(1):1.

    [2] Xiao XH, Jin C, Zhao ZZ, et al. China Journal of Chinese Materia Medica, 2007, 32(14):1377.

    [3] Wang JB, Zhang XR Chu XH, et al. China Journal of Chinese Materia Medica, 2010, 35(20):2657.

    [4] iao XH, Wang JB & Yan D. Modernization of Traditional Chinese Medicine and Materia Materia-World Science and Technology, 2014,16(3):514.

    [5] Xiong Y, Xiao XH, Yan D, et al. Chinese Traditional and Herbal Drugs, 2014,45(1):1.

    [6] Xiao XH, Wang JB, Yan D, et al. Establishment of Dao-Di index and its significance in quality control and rational usage of Chinese medicine. Zhongguo Zhong Yao Za Zhi, 2012,37(11):1513.

    [7] Wang JB, Zhang XR, Xiao XH, et al. China Journal of Chinese Materia Medica, 2010,35(4):470.

    [8]Wang J B,Zeng L N,Zang Q C,et al.Colorimetric grading scale can promote the standardization of experiential and sensory evaluation in quality control of traditional Chinese medicines[J].PLo S ONE,2012,7 (11 ):e48887.

    [9] Zhang XR,Wang JB, Xiao XH, et al. Chinese Traditional and Herbal Drugs, 2010,41(8):1225.

    [10] Yang G, Zeng Y, Guo LP, et al. China Journal of Chinese Materia Medica, 2014, 39(9): 1733.

    [11] Xiong Y, Yan D, Wang JB, et al. Biopotency assays: an integrated application to quality control of Chinese material medica. Chinese Herbal Medicines, 2014,6(4):256.

    [12]Liu C X.Biopotency assays,a model with integration feature for quality control research of CMM[J].Chin Herb Med,2014,6 (4 ):255 .

    [13] Yan D, Xiao XH. China Journal of Chinese Materia Medica, 2011,36(9):1249.

    [14] Zhao YL, Qu F, Xiao XH, et al. Chinese Journal of Integrated Traditional and Western Medicine, 2006(7):628.

    [15] Wang JB, Jin C, Li HF, et al. Essential issues of bioassay methods for quality control of laxative traditional Chinese medicines. Acta Pharmaceutica Sinica, 2009, 44 (5): 500.

    [16] Wang YH, Wang JB, Hao QX, et al. Chinese Journal of Experimental Traditional Medical Formulae, 2014,20(9):77.

    [17] Li HB, Yan D, Wang JB, et al. Acta Pharmaceutica Sinica, 2009,44(2):162.

    [18]Luo J Y,Yan D,Song J Y,et al.A strategy for trade monitoring and substitution of the organs of threatened animals[J].Sci Rep,2013,3 :3108.

    [19] Luo Y, Jin C, Zhou J, et al. Acta Pharmaceutica Sinica,2011,46(4):438.

    [20] Lv Y. Fleece-flower root quality control based on liver cell toxic price detection method research. Beijing: Master thesis, Beijing university of chemical industry, 2013.

    [21]Qin Y,Wang J B,Zhao Y L,et al.Establishment of a bioassay for the toxicity evaluation and quality control of Aconitum herbs[J].J Hazard Mater,2012,15 :350 .

    [22] Liu XX, Dong L, Zhang XH, et al. China Journal of Chinese Materia Medica, 2014, 39(19): 3764.

    [23] Chen GY,Wu QN,WangXS,et al. China Journal of Chinese Materia Medica, 2012,37(19):2913.

    [24] Dai XJ, Song J, Yan lc, et al. Sichuan zhongyi, 2013,31(9):43.

    [25] Qin Y Establishment of the quality assessment model of Aconitum toxic herbs based on bioassay. Kunming: Master thesis, Kunming university of science and technology, 2010.

    [26] Xiao XH, Xia WJ, Chen SY. China Journal of Chinese Materia Medica, 1995,20(6): 323.

    [27] Zhao RH, Wang JY, Sun CZ, et al. Modern Chinese Medicine, 2006,8(7): 4.

    [28] Chen SL, Suo FM, Han JP, et al. Chinese Traditional and Herbal Drugs, 2007,38(4): 481.

This Article

ISSN:1001-5302

CN: 11-2272/R

Vol 40, No. 01, Pages 7-12

January 2015

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Knowledge

Abstract

  • 1 Present situation and problems of CMM research
  • 2 An integrated QCE system for CMM: the proposal of CP
  • 3. Conclusion
  • References