Studies of flavonoids from Radix Glycyrrhizae
(2.Xiangxue Academician Workstation, Xiangxue Pharmaceutical Co., Ltd., Guangzhou, China 510663)
【Abstract】 Objective To study the chemical constituents of flavonoids from Radix Glycyrrhizae. Methods The compounds were isolated and purified by column chromatography over HP-20 macroporous resin, silica gel, Sephadex LH-20, and preparative RP-HPLC. Their structures were elucidated by physicochemical properties and spectral analysis. Results Ten flavonoids were isolated and identified as 4′,6,7-trihydroxy-2′-methoxyl-chalcone (1), 3′,4′,5,7-tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-isoflavone (2), isoliquiritigenin (3), isoliquiritin (4), echinatin (5), orobol (6), ononin (7), 2(S)-3′,5′,7-trihydroxyflavanone (8), 2(S)-naringenin-4′-O-β-D-glucopyranoside (9), and 4′,7-dihydroxyflavone (10). Conclusion Compounds 1 and 2 are new compounds named isolicochalcone B and licoisoflavone G, while compound 9 is isolated from the genus for the first time.
【Keywords】 Radix Glycyrrhizae; flavonoids; isolicochalcone B; licoisoflavone G; isoliquiritin; echinatin; orobol; ononin; 2(S)-naringenin-4′-O-β-D-glucopyranoside;
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