Studies of flavonoids from Radix Glycyrrhizae

HU Geng1,2 HUANG Qi-yun2 ZHANG Tian1,2 MEI Yu-dan2 TANG Xi-yang1 MENG He2 YU Yang1 DAI Yi1 YAO Xin-sheng1

(1.Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, China 510632)
(2.Xiangxue Academician Workstation, Xiangxue Pharmaceutical Co., Ltd., Guangzhou, China 510663)

【Abstract】 Objective To study the chemical constituents of flavonoids from Radix Glycyrrhizae. Methods The compounds were isolated and purified by column chromatography over HP-20 macroporous resin, silica gel, Sephadex LH-20, and preparative RP-HPLC. Their structures were elucidated by physicochemical properties and spectral analysis. Results Ten flavonoids were isolated and identified as 4′,6,7-trihydroxy-2′-methoxyl-chalcone (1), 3′,4′,5,7-tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-isoflavone (2), isoliquiritigenin (3), isoliquiritin (4), echinatin (5), orobol (6), ononin (7), 2(S)-3′,5′,7-trihydroxyflavanone (8), 2(S)-naringenin-4′-O-β-D-glucopyranoside (9), and 4′,7-dihydroxyflavone (10). Conclusion Compounds 1 and 2 are new compounds named isolicochalcone B and licoisoflavone G, while compound 9 is isolated from the genus for the first time.

【Keywords】 Radix Glycyrrhizae; flavonoids; isolicochalcone B; licoisoflavone G; isoliquiritin; echinatin; orobol; ononin; 2(S)-naringenin-4′-O-β-D-glucopyranoside;

【DOI】

【Funds】 Guangdong Science and Technology Plan Project (2015B030301005)

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This Article

ISSN:0253-2670

CN: 12-1108/R

Vol 50, No. 21, Pages 5187-5192

November 2019

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Article Outline

Abstract

  • 1 Instruments and materials
  • 2 Extraction and isolation
  • 3 Structural identification
  • References