Study on effective components and mechanism of Dachaihu Decoction in treatment of pancreatitis due to liver depression and qi stagnation

SUN Kai-bin1,2 LI Xiao-yu2 ZHANG Xin-yu2 HUANG Na-na1 SUN Rong1,3

(1.The Second Hospital of Shandong University, Jinan, Shandong Province, China 250033)
(2.Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China 250355)
(3.Advanced Medical Research Institute, Shandong University, Jinan, Shandong Province, China 250012)

【Abstract】 Objective To study the effective components and mechanism of action of Dachaihu Decoction (DCHD) in the treatment of pancreatitis due to liver depression and qi stagnation. Methods Based on network pharmacology, the PPI network of Chinese herbs capable of soothing liver and regulating qi and the “Chinese herbs-effective components-key target” network of DCHD in the treatment of pancreatitis due to liver depression and qi stagnation were constructed using Cytoscape 3.6.0. Then the intersections between the two networks were screened out to obtain the “Chinese herbs-effective components-key target” network of DCHD for treating acute pancreatitis due to liver depression and qi stagnation. Results A total of 59 key targets for soothing liver and regulating qi were obtained, including AKT1, VEGFA, and PRSS1. A total of 83 main active components such as quercetin, kaempferol and baicalein were collected from DCHD. The treatment of pancreatitis due to liver depression and qi stagnation relied on 18 targets for liver depression and qi stagnation such as PTGS2, DPP4, and PRSS1, and 30 related biological processes and signaling pathways such as extracellular matric disassembly, IL-17 signaling pathway, and AGE-RAGE signaling pathway in diabetic complications. Conclusion The multiple components in DCHD are the basis for its treatment of pancreatitis via multiple targets. It is worthwhile to explore the Chinese herbal compound based on network pharmacology.

【Keywords】 Dachaihu Decoction; pancreatitis; network pharmacology; effective components; liver depression and qi stagnation;

【DOI】

【Funds】 Key Research and Development Project of Shandong Province (2016ZDJS07A21) Key Research and Development Project of Shandong Province (2016CXGC1301) General Projects of National Natural Science Foundation of China (81773997) Taishan Scholars Program of Shandong Province (ts20151107)

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This Article

ISSN:0253-2670

CN: 12-1108/R

Vol 50, No. 21, Pages 5125-5134

November 2019

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Article Outline

Abstract

  • 1 Methods
  • 2 Results
  • 3 Discussion
  • References