Study on shedding particles from Chuanping Sustained-release Tablets based on multi-marker components balanced release

CAI Yan-qu1 LI Bi-yun1 ZHONG Xiao-yu1 ZHU Sheng-shan1 CAI Ting2 HUO Wu-zhen1 LI Yuan-xin1 WU Yan-hong1

(1.Center for Drug Research and Development, Guangdong Pharmacological University, Guangzhou, China 510006)
(2.Jianmin Pharmaceutical Group Co., Ltd., Wuhan, China 430000)

【Abstract】 Objective To study the changes of shedding particles, drug loading, and release of Chuanping Sustained-release Tablets (CST) which were made by the different sustained-release excipients in vitro, so as to elucidate the mechanism about balanced release of multi-marker components on Chinese medicinal compound sustained-release preparation. Methods Using Chuanping Prescription (Herba Ephedraeand Flos Daturae) as model drug and improved peach gum and HPMC as sustained release materials, the release test combinied with underwater video observation were applied to shot external forms at different time points, and the laser particle analyzer was applied to determinate particle size. HPLC was applied to determine the accumulated release rate of the index components (ephedrine, pseudoephedrine, and scopolamine) to calculate the cumulative release curve slope K value, and to evaluate the balanced release of the different components. Results For CST which were made by the improved peach gum and HPMC sustained-release excipient, particles were dropped at 0.5 h after contacting the dissolution medium. At the same time, the particles were obviously shedded over time. In contrast, for CST that were made by the improved peach gum, its balanced release of multi-marker components was better (K of ephedrine was 12.18; K of pseudoephedrine was 12.30, and K of scopolamine was 12.40), and particles dropped faster (it was significantly at 1 h); particle size was larger (D50 was 53.37–70.33 μm and D90 was 100.3–196.5 μm), and drug loading was higher (ephedrine 30.63%, pseudoephedrine 32.97%, and scopolamine 31.67%); besides, the release time of drug was longer (60–120 min). Conclusion The shedding particles were important part of balanced release of multi-marker components about CST which were made by the improved peach gum sustained-release excipient, and also were the embodiment of the drug release mode of “corrosion–dissolution”.

【Keywords】 shedding particles; balanced release; multi-marker components; improved peach gum; HPMC; sustained release; in vitro release; particle size; laser particle analyzer; HPLC;


【Funds】 National Natural Science Foundation of China (81503260) National Natural Science Foundation of China (81373981)

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(Translated by ZHAO B)


    [1] Cai Y Q, Chen J, Xie J F et al. Evaluation of balanced release of complex components of Chuanping sustained tablets based on fingerprint [J]. China J Chin Materia Medica, 2013, 38 (9): 1360–1365 (in Chinese).

    [2] Zhong X Y, Wu S P, Huo F Z et al. Release mechanism of Chuanping sustained-release tablets [J]. Tradit Chin Drug Res Clin Pharmacol, 2014, 25 (5): 599–603 (in Chinese).

    [3] Chinese Pharmacopoeia [S]. Volume IV. 2015 (in Chinese).

    [4] Tian X D, Zhu S S, Wu S P et al. Influence of different compatibility for improved peach gum to balance release of complex components [J]. Chin Tradit Herb Drugs, 2015, 46 (8): 1140–1144 (in Chinese).

    [5] Sun S, Xu Y M, Liu D L et al. Determination of particle size of calcium carbonate by laser particle size analyzer [J]. Polyest Ind, 2017, 30 (6): 30–32 (in Chinese).

    [6] Pan L S, Ge B Z, Zhang F G. Laser particle size measurement based on annular sample cell [J]. Acta Opti Sin, 2017, 37 (10): 311–319 (in Chinese).

    [7]Naqarwal R C, Ridhurkar D N, Pandit J K.In vitro release kinetics and bioavailability of gastroretentive cinnarizine hydrochloride tablet[J].AAPS PharmSciTech, 2010, 11 (1): 294–303.

    [8] Cai Y Z, Zhu S S. Preparation and application of a modified peach resin slow-release material: China, 10773522. X [P]. 2018-05-01 (in Chinese).

    [9] Cai Y D, Liu J, Li Y X et al. Study on balanced release of Chuanping extract sustained-release tablets combined with different accessories [J]. Chin Tradit Herb Drugs, 2014, 45 (6): 774–777 (in Chinese).

    [10] Cai Y D, Dong B L, Zhu Z D et al. Changes of polysaccharide content, functional properties and in vitro release of peach gum before and after improvement [J]. Chin Tradit Herb Drugs, 2018, 49 (20): 4808–4815 (in Chinese).

    [11] Cai T, Cai Y Q, Xu J N et al. Research on release rate of traditional Chinese medicine xj compound whole powder sustained-release tablets in vitro [J]. J Guangzhou Univ Tradit Chin Med, 2017, 34 (1): 101–107 (in Chinese).

This Article



Vol 50, No. 04, Pages 836-843

February 2019


Article Outline


  • 1 Instruments and test drugs
  • 2 Methods and results
  • 3 Discussion
  • References