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李帅锋1,2 丁安伟 张丽 兰才武3 贺定翔

(1.南京中医药大学 江苏省中药资源产业化过程协同创新中心/中药资源产业与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023)
(2.苏州市中医院, 江苏 苏州 215003)
(3.贵州昌昊中药发展有限公司, 贵州 凯里 556000)

【摘要】目的 优选何首乌Polygoni Multiflori Radix产地加工与饮片炮制一体化工艺, 为何首乌产地加工与饮片炮制一体化工艺提供科学依据。方法 采用正交试验法对一体化加工工艺中烘干温度、时间这2个显著影响因素进行考察。以何首乌中指标性成分二苯乙烯苷、结合蒽醌质量分数为考察指标, 通过综合评分法对一体化工艺进行优选研究;以小肠推进率、首次排便时间及粪便含水量为指标, 比较2种工艺“润肠通便”的作用;以小鼠耳廓肿胀度及炎症因子为指标, 比较2种工艺饮片的抗炎作用。结果 优选结果显示, 新鲜何首乌切6 mm厚片, 置于干燥箱内在50℃下烘16 h的工艺较优;与《中国药典》2015年版中的传统工艺所得饮片相比, 一体化工艺所得饮片指标成分及润肠通便作用没有显著性差异, 抗炎效果优于传统工艺。结论 何首乌产地加工与饮片炮制一体化工艺切实可行, 可操作性强。

【关键词】 何首乌;产地加工与饮片炮制一体化工艺;传统工艺;正交试验;综合评分法;润肠通便;抗炎;二苯乙烯苷;结合蒽醌;


【基金资助】 国家“十二五”科技支撑计划项目 (2011BAI13B04) ; 江苏省中药资源产业化过程协同创新中心重点项目 (ZDXM-1-3) ; 江办高校优势学科建设工程资助项目 (ysxk-2014) ; 江苏高校品牌专业建设工程资助项目 (PPZY2015A070) ; 贵州省中药现代化专项 (黔科合中药字[2013]5059号) ;

Optimization of integration of field processing and processing crude drugs of Polygoni Multiflori Radix

LI Shuai-feng1,2 DING An-wei1 ZHANG Li1 LAN Cai-wu3 HE Ding-xiang3

(1.Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, China 210023)
(2.Suzhou Hospital of Chinese Medicine, Suzhou, Jiangsu Province, China 215003)
(3.Guizhou Changhao Chinese Medicine Development Co., Ltd., Kaili, Guizhou Province, China 556000)

【Abstract】Objective To optimize a technology of integration on field processing and processing crude drugs of Polygoni Multiflori Radix (PMR) and to provide the scientific evidence for the integration of PMR. Methods Orthogonal test was used to optimize the integration technology on primary processing and reprocessing with two major characteristic components (stilbene glucoside and combined anthraquinone). To compare the differences between the integration technology and traditional technology on pharmacological activity by models of constipation and swelling of ear in mice with Various index (small intestinal propulsion rate, first defecation time, fecal water content, swelling degree of ear, and inflammatory factors). Results The results showed that the integration technology of 50 °C, 16 h was better, and there was significant difference in chemical composition and laxative effect between the integration technology and traditional technology. The anti-inflammatory effect of the integrated process was better than that of the traditional technology. Conclusion The technology of integration of field processing and processing crude drugs is feasible and the operation is good.

【Keywords】 Polygoni Multiflori Radix; integration technology of field processing and processing crude drugs; traditional technology; orthogonal test; comprehensive scoring method; laxative effect; anti-inflammation; stilbene glucoside; combined anthraquinone;


【Funds】 National “Twelfth Five-Year” Science and Technology Support Program (2011BAI13B04); Key Project of Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization (ZDXM-1-3); Jiangsu University Advantage Discipline Construction Program (ysxk-2014); Brand Professional Construction Project of Jiangsu Universities (PPZY2015A070); Specific Program of Traditional Chinese Medicine Modernization of Guizhou Province (QKHZYZ [2013] 5059);

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    [1] Chinese Pharmacopoeia [S]. Volume One. 2015 (in Chinese).

    [2] MEI X, YU LQ, CHEN XY, et al. Advances in studies on the chemical components and pharmacological activities of Radix Polygoni multiflori [J]. Drug Evalution Research, 2016, 39 (1): 122–131 (in Chinese).

    [3] LUO YY, LIU JX, LIU XH, et al. Determination of multiple functional substances in different processed products of Polygoni Multiflori Radix and principal component analysis [J]. Chinese Traditional and Herbal Drugs, 2016, 47 (2): 318–323 (in Chinese).

    [4] XIANG CK, WANG R, YUAN ZF. Study on effect of polygonum mutiflorum extract on lipid metabolism and its antioxidation in SD rats with hyperlipemia [J]. China Pharmaceuticals, 2009, 18 (24): 19–20 (in Chinese).

    [5] LU LS, TANG J, Ho CT. Chemical studies of the antioxidant mechanism of stilbene glucose from polygonum multiflorum thunb:radical reaction products of stilbene glucosides with DPPH [J]. Food and Machinery, 2007, 23 (5): 93–97 (in Chinese).

    [6] SUN GB, DENG XC, GUO BJ, et al. Study on anti-tumor effects of anthraquinone glycosides from Polygonum multiflorum [J]. Chinese Journal of New Drugs, 2008, 17 (10): 837–841 (in Chinese).

    [7] SUN GB, GUO BJ, LI XE, et al. The effect of anthraquinone glycoside from Polygonum multiflorum Thunb on cellular immunological function in mice [J]. Pharmacology and Clinics of Chinese Materia Medica, 2006, 22 (6): 30–32 (in Chinese).

    [8] GAO Q, XU HQ, CHEN JW, et al. Liver-protective and bowel-lubricating and defecation-promoting effects of crude and processed Semen Cassiae [J]. Traditional Chinese Drug Research and Clinical Pharmacology, 2007, 3 (18): 194–196 (in Chinese).

    [9] YANG YJ, LAN CW, HE DX, et al. Effect of Different Processing Methods on Quality of Polygoni Multiflori Radix Decoction [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2015, 15 (21): 31–34 (in Chinese).

    [10] QIAN Y, YU S, SHAN MQ, et al. Optimization of integrated processing technology for medicinal materials and decoction pieces of Chaenomeles speciosa by Box-Behnken design and response surface method [J]. Modern Chinese Medicine, 2015, 10 (17): 1065–1069 (in Chinese).

    [11] TIAN YH, ZHANG LY, YANG YQ, et al. Optimization of processing technologies for Heshouwu habitat by colligation score [J]. Lishizhen Medicine and Materia Medica Research, 2007, 11 (18): 2668–2669 (in Chinese).

    [12] YAO WF, HE M, JIANG YJ, et al. Extraction technology of Erzhi Pills based on weighted score of multi-index [J]. Chinese Traditional Patent Medicine, 2013, 35 (7): 1414–1418 (in Chinese).

    [13] TANG DX, TAN ZH, LIANG YY, et al. The inducing diarrhea effects and its mechanisms of anthraquinon from Rheum palmatum L. [J]. Lishizhen Medicine and Materia Medica Research, 2007, 6 (18): 1312–1314 (in Chinese).

    [14] ZHAO YL, ZHANG ZH, WANG ZR, et al. Relationship between drastic effect of Rhubarb and 5-HT and it’s receptor in duodenum tissues [J]. Journal of Yunnan College of Traditional Chinese Medicine, 2002, 25 (1): 1–3 (in Chinese).

    [15] JIA ZB. Composition and function study of anthraquinone compounds in Cassia obtusifolia L. [D]. Jiangsu: Jiangnan University, 2006 (in Chinese).

This Article


CN: 12-1108/R

Vol 47, No. 17, Pages 3003-3008

September 2016


Article Outline


  • 1 Instruments and materials
  • 2 Methods and results
  • 3 Discussions
  • References