Optimization of integration of field processing and processing crude drugs of Polygoni Multiflori Radix

LI Shuai-feng1,2 DING An-wei1 ZHANG Li1 LAN Cai-wu3 HE Ding-xiang3

(1.Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, China 210023)
(2.Suzhou Hospital of Chinese Medicine, Suzhou, Jiangsu Province, China 215003)
(3.Guizhou Changhao Chinese Medicine Development Co., Ltd., Kaili, Guizhou Province, China 556000)

【Abstract】Objective To optimize a technology of integration on field processing and processing crude drugs of Polygoni Multiflori Radix (PMR) and to provide the scientific evidence for the integration of PMR. Methods Orthogonal test was used to optimize the integration technology on primary processing and reprocessing with two major characteristic components (stilbene glucoside and combined anthraquinone). To compare the differences between the integration technology and traditional technology on pharmacological activity by models of constipation and swelling of ear in mice with Various index (small intestinal propulsion rate, first defecation time, fecal water content, swelling degree of ear, and inflammatory factors). Results The results showed that the integration technology of 50 °C, 16 h was better, and there was significant difference in chemical composition and laxative effect between the integration technology and traditional technology. The anti-inflammatory effect of the integrated process was better than that of the traditional technology. Conclusion The technology of integration of field processing and processing crude drugs is feasible and the operation is good.

【Keywords】 Polygoni Multiflori Radix; integration technology of field processing and processing crude drugs; traditional technology; orthogonal test; comprehensive scoring method; laxative effect; anti-inflammation; stilbene glucoside; combined anthraquinone;

【DOI】

【Funds】 National “Twelfth Five-Year” Science and Technology Support Program (2011BAI13B04) Key Project of Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization (ZDXM-1-3) Jiangsu University Advantage Discipline Construction Program (ysxk-2014) Brand Professional Construction Project of Jiangsu Universities (PPZY2015A070) Specific Program of Traditional Chinese Medicine Modernization of Guizhou Province (QKHZYZ [2013] 5059)

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This Article

ISSN:0253-2670

CN: 12-1108/R

Vol 47, No. 17, Pages 3003-3008

September 2016

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Abstract

  • 1 Instruments and materials
  • 2 Methods and results
  • 3 Discussions
  • References