Preparation of molecular imprinted polymers for solid-phase extraction of L-tetrahydropalmatine

ZHU Jun-fang1 LI Bo1

(1.Guangdong Food and Drug Vocational College, Guangzhou, China 510520)

【Abstract】Objective To prepare the molecularly imprinted polymer (MIPs) of L-tetrahydropalmatine (L-THP) by the molecular imprinting technique and study on solid-phase extraction. Methods Using L-THP as template, methyl acrylic acid (MAA) as functional monmer, and ethylene glycol dimethacrylate (EDMA) as a cross-linking agent to prepare the L-THP-MIPs. A test was conducted to investigate the selectivity and the specificity of solid-phase extraction. Results The experiment showed that the MIPs had the specific adsorption to L-THP, but did not have the specific adsorption to corydaline the structural analogue with L-THP. Conclusion The L-THP-MIPs have a good selectivity and the specificity of L-THP.

【Keywords】 molecular imprinting technique; molecularly imprinted polymer; L-tetrahydropalmatine; solid-phase extraction; methyl acrylic acid; ethylene glycol dimethacrylate; corydaline;


【Funds】 Research Fund of Medical Science and Technology of Guangdong Province, China (A2015470) Natural Science Foundation of Guangdong Food and Drug Vocational College (2014YZ010)

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This Article


CN: 12-1108/R

Vol 47, No. 01, Pages 72-75

January 2016


Article Outline


  • 1 Instruments and materials
  • 2 Method
  • 3 Results and discussion
  • 4 Discussion
  • References