Study on preparation technology of nano spray drying for Rehmanniae Radix oligosaccharide micro-powders
【Abstract】Objective To prepare Rehmanniae Radix oligosaccharide micro-powders with high load capacity, high yield, and good moisture absorption, using nano spray drying technology. Methods Based on the single factor experiments, the B-90 spray dryer was used to prepare Rehmanniae Radix oligosaccharide micro-powders with average particle size, yield, and moisture absorption rate as evaluation indices, and orthogonal test was used to investigate the influence of inlet temperature, spray drying efficiency, and solution concentration on the preparation process and to optimize the preparation process. Results The best spray drying condition was A2B2C3, namely the inlet temperature was 110 °C, the spray drying efficiency was 50%, and the drug concentration was 1%. Finally the drug loading was 30% and the yield was 89% with good moisture absorption. The Rehmanniae Radix oligosaccharide micro-powders had good morphology stability. Conclusion The nano spray drying technology is stable and the micro-powders have good quality, which is better than the traditional spray drying technology.
【Keywords】 Rehmanniae Radix; nano spray drying; average particle size; yield; moisture absorption; drug loading; orthogonal test;
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