Mechanisms of anti-inflammation of taurochenodeoxycholic acid based on network pharmacology

LI Lei1 TUMEN Ba-ya-er2 LI Pei-feng3 LIU Chang1 LI Sheng-he1 NING Kang-jian1 JIANG Jin-peng1

(1.Key Laboratory of Quality and Safety Control for Pork, Ministry of Agriculture and Rural, College of Animal Science, Anhui Science and Technology University, Fengyang, China 233100)
(2.Shanxi Animal Disease Control Center, Taiyuan, China 030027)
(3.Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture and Rual, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China 010018)

【Abstract】To investigate the anti-inflammatory mechanisms of taurochenodeoxycholic acid (TCDCA), the molecule structure file of TCDCA was downloaded from PubChem database, PharmMapper and GeneCards were used to predict and screen the targets of TCDCA. STRING database and Cytoscape software were used to construct protein interactions network. GO and KEGG analysis was preformed through STRING database. The key targets were validated by molecular docking and the targets type was attributed by DisGeNET database. The network showed that 89 targets were involved in 68 biological processes including response to stimulus, multicellular organismal process, single-multicellular organism process, response to chemical, response to organic substance, by adjusting 51 signaling pathways, such as pathways in cancer, progesterone-mediated oocyte maturation, MAPK signaling pathway, proteoglycans in cancer. These findings provide an overview of anti-inflammation of TCDCA, which reflects the characteristic of multi-targets and multi-pathways of TCDCA. It pointed out the direction for further research on anti-inflammatory mechanism of TCDCA.

【Keywords】 taurochenodeoxycholic acid; inflammation; network pharmacology; pharmacological mechanism; molecular docking;


【Funds】 National Natural Science Foundation of China (31802242) Key Program of National Natural Science Foundation of Univerisities in Anhui Province (KJ2017A503, KJ2017A504) Program for Talents Introduction of Anhui Science and Technology University (ZRC2014447) Key Disciplinary Construction of Anhui Science and Technology University (AKZDXK2015A04)

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This Article


CN: 11-2163/R

Vol 53, No. 12, Pages 2064-2075

December 2018


Article Outline


  • Materials and methods
  • Results
  • Discussion
  • References