Action Mechanism of Linggui Zhugan Decoction for the Treatment of Heart Failure Based on Network Pharmacology

XIE Xuan1 WANG Qing1 SU Congping1 LIU Jinying1 ZHANG Shihan1 WANG Wei1 GUO Shuzhen1

(1.School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China 100029)
【Knowledge Link】congestive heart failure

【Abstract】Objective: To explore the potential targets of Linggui Zhugan Decoction for the treatment of heart failure by using network pharmacology. Methods: A bioinformatics analysis website for traditional Chinese medicine (BATMAN-TCM) was used to predict and screen the possible active components of Linggui Zhugan Decoction in the intervention of heart failure and its targets for heart failure. The Cytoscape software was used to construct a target-component network for the treatment of heart failure with Linggui Zhugan Decoction and its single medicines. Venn diagram (Venny 2.1) was used to further study the mechanism of Poria and Radix et Rhizoma Glycyrrhizae of Linggui Zhugan Decoction in the treatment of heart failure. Results: A total of 79 active components in the Linggui Zhugan Decoction were screened out from the results. There were 18 targets associated with heart failure, and the active components and targets were closely related. The 18 targets obtained mainly included: ACE; ADRA2 A; ADRA2 B and so on. The target number of Radix et Rhizoma Glycyrrhizae in Linggui Zhugan Decoction was the largest that it accounted for 94.4%of the total targets of the decoction in the treatment for heart failure. Conclusion: The mechanism of Linggui Zhugan Decoction in improving heart failure may be related to the decrease of Ang II, the inhibition of RAS activity, and the regulation of sympathetic nervous system, etc. Among which, Radix et Rhizoma Glycyrrhizae is the most prominent in the aspect of Linggui Zhugan Decoction in treating heart failure.

【Keywords】 Linggui Zhugan Decoction; Network pharmacology; Poria; Radix et Rhizoma Glycyrrhizae; Heart failure; Target;

【DOI】

【Funds】 National Natural Science Foundation of China (81874387) Special Fundamental Research Fund for the Central Universities and Colleges (2018-JYBZZ-XS024)

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This Article

ISSN:1673-7202

CN:11-5529/R

Vol 14, No. 05, Pages 1110-1115

May 2019

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Abstract

  • 1 Materials and methods
  • 2 Results
  • 3 Discussion
  • References