Accurate Characterization of Spatial Orientations of Fiber-Like Structures in Biological Tissues and Its Applications

LIU Zhiyi1 MENG Jia1 QIU Jianrong1 HAN Tao1 WANG Di1 ZHUO Shuangmu2 DING Zhihua1

(1.State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, Zhejiang, China 310027)
(2.Key Laboratory of Opto-Electronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, Fujian, China 350007)
【Knowledge Link】Fourier transform

【Abstract】Fiber-like structure is one of the basic structures found in biological tissues. The spatial orientations of fiber-like structures change with the initiation and progression of some diseases. In this study, we present a brief overview of quantitative orientation analysis methods for fiber-like structures within biological tissues and main applications of these methods. We especially focus on the research progress of spatial orientation information in important disease models, including wound healing, osteoarthritis, breast cancer, peritoneal metastasis, and brain injury. Additionally, we explore the relations between tissue structure and function via specific engineered tissues. A highly sensitive and highly accurate description of the fiber-like structures within biological tissues serves as a novel method for studying disease initiation and progression, shows potential for early disease diagnosis, and improves our understanding of the mechanisms underlying some disorders. Finally, future potential applications of the orientation analysis methods are explored.

【Keywords】 medical optics; fiber-like structure; spatial orientation; three-dimensional organization; osteoarthritis; cancer; brain-like tissue; multi-photon imaging;


【Funds】 National Key Basic Research Program of China (2017YFA0700501) National Natural Science Foundation of China (11974310, 61905214, 31927801) Zhejiang Provincial Natural Science Foundation (LR20F050001) Fundamental Research Funds for the Central Universities of Ministry of Education of China (2019QNA5004)

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(Translated by REN XF)


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This Article


CN: 31-1339/TN

Vol 47, No. 02, Pages 22-35

February 2020


Article Outline



  • 1 Introduction
  • 2 Quantitative characterization method of spatial orientation of fiber-like structures
  • 3 Application of spatial orientation information in biomedicine
  • 4 Conclusion
  • References