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炭团木霉Trichoderma hypoxylon中一个新倍半萜

吴洪波1,2 陈林2,3 吕海宁2 刘欢2 汪世华1 尹文兵2

(1.福建农林大学生命科学学院, 福建福州 350002)
(2.中国科学院微生物研究所真菌学国家重点实验室, 北京 100101)
(3.黄河科技学院郑州市药用资源研究重点实验室, 河南郑州 450063)

【摘要】木霉属Trichoderma真菌能够产生大量的活性次级代谢产物, 是农业和工业应用的重要资源库。通过对1株炭团木霉Trichoderma hypoxylon的化学研究, 从其大米发酵物中分离到6个化合物, 通过核磁共振、质谱、紫外和红外等光谱手段鉴定其结构分别为:tichodermacid (1) 、3-吲哚乙酸甲酯 (2) 、3-吲哚乙酸 (3) 、1-乙酰基-β-咔啉 (4) 、monaspilosin (5) 和hydroheptelidic acid (6) 。其中化合物1为新倍半萜。

【关键词】 炭团木霉;次级代谢产物;倍半萜;


A new sesquiterpenoid from Trichoderma hypoxylon

WU Hong-Bo1,2 CHEN Lin2,3 LV Hai-Ning2 LIU Huan2 WANG Shi-Hua1 YIN Wen-Bing2

(1.College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China 350002)
(2.State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China 100101)
(3.Huanghe Science and Technology College, Zhengzhou Key Laboratory of Medicinal Resources Research, Zhengzhou, Henan, China 450063)

【Abstract】Fungi of Trichoderma genus produce plenty of bioactive secondary metabolites and are very important sources for industrial and agricultural applications. Here, we conducted the chemical study of Trichoderma hypoxylon, and isolated six compounds from the rice fermentation. Their structures were elucidated by NMR, mass spectrometry, ultraviolet and infrared spectroscopy, and identified as trichodermacid (1), 3-indole-methylethanoate (2), 3-indole-acetic acid (3), 1-acetyl-β-carboline (4), monaspilosin (5), and hydroheptelidic acid (6). Compound 1 was found to be a new sesquiterpenoid.

【Keywords】 Trichoderma hypoxylon; secondary metabolites; sesquiterpenoid;


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This Article


CN: 11-5180/Q

Vol 38, No. 04, Pages 533-538

April 2019


Article Outline


  • 1 Materials and methods
  • 2 Results and analyses
  • 3 Discussion
  • References