Research on Epidemiological Characteristics and Etiology of Hand, Foot and Mouth Disease in Jiangxi Province, China, 2009–2017
【Abstract】The epidemiological characteristics of hand, foot and mouth disease (HFMD) in Jiangxi Province, China, between 2009 and 2017 were analyzed and the epidemic trend was explored, so as to provide scientific basis for the prevention and treatment of HFMD. The genetic characteristics of enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) were analyzed. The HFMD epidemic data of Jiangxi Province were collected based on the China Disease Reporting Information System for descriptive epidemiological analysis from 2009 to 2017. There were 373 966 HFMD cases reported during this period in Jiangxi Province. The average annual incidence was 92.33/100 000. The incidence of HFMD showed obvious seasonal variation with peak seasons in summer and winter. The cases mainly occurred in children under 5 years old. The proportion of other enterovirus infections was increased, accounting for 44.10% of the cases diagnosed in the laboratory. Severe cases and death cases were mainly EV-A71 infection. The gene determination and analysis of 34 EV-A71 isolates from HFMD in Jiangxi Province showed that the EV-A71 isolates belong to the C4a evolutionary branch of the C4 gene subtype. Gene determination and analysis of VP1 coding region of 27 HFMD isolates in Jiangxi Province showed that the CV-A16 isolates belong to the B1 gene subtype. HFMD prevention and control work was focused on publicity and education for parents of small age group children. It is necessary to carry out the detection of other enteroviruses, understand the pathogen and conduct early prevention. It is necessary to speed up the use and promotion of enterovirus EV-A71 vaccine, so as to reduce the incidence of severe case of HFMD and death cases and the burden of disease.
【Keywords】 Hand, foot and mouth disease (HFMD) ; Epidemiological analysis; Other enteroviruses;
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