Sponsor(s):Institute of Chinese Pharmaceutical Association
24 issues per year
Current Issue: Issue 11, 2021
Journal official website:http://zgzye.cbpt.cnki.net/WKE/WebPublication/index.aspx?mid=zgzye
China Journal of Chinese Materia Medica, the 1st in the field of TCM, is supervised by China Association for Science and Technology and sponsored by Institute of Chinese Pharmaceutical Association. The journal is China's earliest comprehensive core journal of traditional Chinese medicine, and always maintains the circulation top in the professional areas. The journal publishes the latest research and progress of traditional Chinese medicine and takes a leading position in numbers of articles published, downloads and citations among all journals in this discipline. Its scope covers new achievements, technologies, methods, experiences and concepts resulting from the research on Chinese materia medica pursuant to Chinese medical and pharmaceutical theories, traditional experiences, and modern science and technology, including medicinal resources and identification, cultivation, processing, preparation, chemistry, pharmacology, theory of Chinese pharmacy and clinical practice, bencaological study. The journal is included in CA, JST and CSCD.
Zhang Boli, Hu Zhibi, Yao Xinsheng, Li Lianda, Li Dapeng, Yang Baofeng, Zhou Chaofan, Huang Luqi, Chen Shilin, Li He.
Executive Editorial Board
Cai Shaoqing, Chen Shilin, Cheng Yiyu, Du Lijun, Du Shouying, Du Zhimin, Gao Wenyuan, Guo Qiaosheng, Guo De’an, Hu Jingqing, Huang Luqi, Liu Hongning, Liu Jianxun, Lv Guiyuan, Qian Zhongzhi, Tu Pengfei, Wang Jie, Wang Zhengtao, Xiao Xiaohe, Yang Xiuwei, Ye Zhengliang, Yu Shishan, Zhang Boli, Zhang Weidong, Zhao Junning,, Zhong Guoyue, Wu hao, Zhu xiaoxin.
Bai Lixi, Bi Kaishun, Bian Baolin, Bian Ka, Cai Shaoqing, Che Zhentao, Chen Changxun, Chen Daofeng, Chen Hubiao, Chen Jijun, Chen Jiachun, Chen Ping, Chen Shilin, Chen Xiangmei, Cheng Yiyu, Cui Xiaolan, Dai Min, Ding Anwei, Du Guanhua, Du Guiyou, Du Lijun, Du Shouying, Du Zhimin, Duan Hongquan, Duan Jin’ao, Dou Qiling, Guo Baolin, Fan Xiaohui, Feng Jianfang, Feng Yi, Gao Weiwei, Gao Wenyuan, Gao Xiumei, Gao Yue, Gao Hao, Gu Jian, Guo Lanping, Guo Qiaosheng, Guo Shunxing, Guo Yujie, Guo Yuewei, Guo De’an, Hao Minghong, He Fuyuan, Hou Shixiang, Hu Jingqing, Hu Jun, Hu Zhibi, Huang Luqi, Huang Wenrong, Jia Tianzhu, Jia Xiaobin, Jiang Ye, Kang Wenyi, Kong Lingyi, Ku Baoshan, Lei Yan, Li Baoxin, Li Bo, Li Dapeng, Li He, Li Jianrong, Li Jiang, Li Lianda, Li Longyun, Li Ping, Li Shao, Li Shaoping, Li Shunxiang, Li Xuejun, Liang Aihua, Liang Rixin, Lin Na, Lin Pengcheng, Lin Ruichao, Lin Sheng, Lin Yaping, Liu Chenghai, Liu Hongning, Liu Jianxun, Liu Liang, Liu Ping, Liu Ping, Liu Xian, Liu Yong, Liu Zhen, Lv Guiyuan, Luo Xiaojian, Luo Yongming, Ma Changhua, Ma Kun, Ma Shuangcheng, Ma Xiaojun, Ma Xingtian, Mao Shengjun, Na Shengsang, Ni Jian, Peng Cheng, Peng Daiyin, Peng Jian, Peng Yong, Qian Zhongzhi, Qiao Shanyi, Qiao Yanjiang, Qin Hailin, Qin Luping, Qiu Minghua, Qu Haibin, Shi Jiangong, Shi Renbing, Shang Xiaoya, Si Jinping, Sun Rong, Sun Xiaobo, Tan Ninghua, Tan Rui, Tang Zhishu, Tang Xudong, Tu Pengfei, Wan Yigang, Wang Chang’en, Wang Jie, Wang Ruwei, Wang Shuoren, Wang Wenping, Wang Xijun, Wang Xiao, Wang Xuan, Wang Xuemei, Wang Yitao, Wang Yonglin, Wang Yongyan, Wang Yuesheng, Wang Zhengtao, Wang Zhibin, Wang Zhimin, Wang Zhong, Wei Lixin, Wu Chunfu, Wu Hao, Wu Lijun, Xiao Hongbin, Xiao Lin, Xiao Peigen, Xiao Wei, Xiao Xiaohe, Xiao Yongqing, Xie Ning, Xie Weidong, Xie Yanming, Xu Hongxi, Xu Qiang, Xu Ximing, Xue Jianping, Yan Dan, Yan Zhiyong, Yang Baofeng, Yang Bin, Yang Hua, Yang Hongjun, Yang Ming, Yang Xiuwei, Yao Xinsheng, Ye Wencai, Ye Zhengliang, Yu Rongmin, Yu Shishan, Zhang Boli, Zhang Qiwei, Zhang Ruixian, Zhang Weidong, Zhang Wensheng, Zhang Yongxiang, Zhang Yujie, Zhang Yunling, Zhao Junning, Zhao Xiaoping, Zhao Yuqing, Zhao Zhongzhen, Zheng Lu, Zhong Guoyue, Zhou Chaofan, Zhu Shengshan, Zhu Xiaoxin, Hiroshi Kurihara(JAP), Lai Shenghan(U.S.), Jia Wei(U.S.), Charlie Changli XUE(AUS), Hiroshi Saito(JAP), Rudolf Bauer(AUT), Peter J.Houfhton(ENG), Il-Moo CHANG(KOR), Tatyana L Kisseleva(RUS)
Effect of C21 steroidal glycoside of Cynanchum auriculatum on liver and kidney fibrosis through TLR4 pathway
China Journal of Chinese Materia Medica,2021,Vol 46,No. 11
The liver and kidney fibrosis model was established by thioacetamide (TAA) and unilateral ureteral ligation in SD rats. The rats were randomly divided into three groups: model group and low- and high-dose groups of C21 steroidal glycoside of Cynanchum auriculatum. Another blank control group was set up. Four weeks later, serum was taken to detect the biochemical indexes of liver and kidney function. Urine protein and urine creatinine were detected by kits. Liver and kidney tissue samples were stained with HE and Masson, and hydroxyproline content was detected. Western blotting was used to detect expressions of fibrotic proteins, inflammatory factors, and TLR4 signaling pathways, so as to observe the preventive and therapeutic effects of C21 steroidal glycoside from C. auriculatum on hepatic and renal fibrosis and explore its molecular mechanism. Four weeks later, serum biochemical results showed that liver and kidney functions were seriously damaged, and pathological sections showed inflammatory cell infiltration, decreased parenchymal cells, and increased interstitial fibrosis in liver and kidney tissues. The results showed that C21 steroidal glycoside at the low and high doses (150 and 300 mg·kg −1) significantly reduced the collagen deposition and the pathological changes of liver and kidney fibrosis as compared with those in the model group. At the same time, we found that the expression levels of TLR4 and MyD88 signaling pathway proteins were significantly increased in the liver and kidney tissues of the model group, and a large number of NF- κB signaling pathway proteins migrated into the nucleus. On the contrary, the expression levels of TLR4 and MyD88 signaling pathway proteins and the nuclear migration of NF- κB were significantly inhibited in the low- and high-dose groups of C21 steroidal glycoside from C. auriculatum. Therefore, it was inferred that the mechanism of C21 steroidal glycoside in preventing and treating liver and kidney fibrosis was related to the inhibition of the TLR4/MyD88/NF- κB inflammatory pathway.