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Brief

China Journal of Chinese Materia Medica, the 1st in the field of TCM, is supervised by China Association for Science and Technology and sponsored by Institute of Chinese Pharmaceutical Association. The journal is China's earliest comprehensive core journal of traditional Chinese medicine, and always maintains the circulation top in the professional areas. The journal publishes the latest research and progress of traditional Chinese medicine and takes a leading position in numbers of articles published, downloads and citations among all journals in this discipline. Its scope covers new achievements, technologies, methods, experiences and concepts resulting from the research on Chinese materia medica pursuant to Chinese medical and pharmaceutical theories, traditional experiences, and modern science and technology, including medicinal resources and identification, cultivation, processing, preparation, chemistry, pharmacology, theory of Chinese pharmacy and clinical practice, bencaological study. The journal is included in CA, JST and CSCD.
Editorial Board

Honorary Editor-in-Chief
Xiao Peigen
Editor-in-Chief
Wang Yongyan

Associate Editors
Zhang Boli, Hu Zhibi, Yao Xinsheng, Li Lianda, Li Dapeng, Yang Baofeng, Zhou Chaofan, Huang Luqi, Chen Shilin, Li He.

Executive Editorial Board
Cai Shaoqing, Chen Shilin

Chemical constituents in chloroform fraction of Houttuynia cordata

YANG Xiao-lu;YANG Yu-ping;GE Yue-wei;MENG Jiang

China Journal of Chinese Materia Medica,2019,Vol 44,No. 02

Pharmacokinetics of Achyranthes bidentata on adjuvant arthritis rats by microdialysis and UHPLC-MS/MS

ZHAN Xiang;WANG Wen-yu;FU Jun;DENG Ran;LI Feng;DAI Xue-jing;WANG Yan;WU Hong

China Journal of Chinese Materia Medica,2019,Vol 44,No. 02

To investigate the “drug-guide” effect of Achyranthes bidentata saponins (ABS) and geniposide (GE) in the treatment on adjuvant arthritis (AA) rats. A UHPLC-MS/MS method for the quantitative determination of GE, zingibroside R 1, ginsenoside Ro and chikusetsu saponin Ⅳa in rat blood and joint dialysate was established. After single or combined administration with ABS and GE to AA rat model, a microdialysis sampling method for rat joint cavity and jugular vein blood vessels was established to collect microdialysis samples. Waters Acquity HSS C 18 column was used to separate the above four components, with acetonitrile-0.1% formic acid water as mobile phase for gradient elution. ESI source was adopted for mass spectra in a negative ion scanning mode. Multiple reaction monitoring (MRM) mode was applied to detect the above four components. The methodological results showed that GE, zingibroside R 1, ginsenoside Ro and chikusetsu saponin Ⅳa demonstrated a good linear relationship within the concentration ranges of 2–4 000, 16–4 096, 14–3 584, 23–5 888 μg·L −1 respectively. The precision, accuracy, stability and matrix effect of these four ingredients reached the requirements of quantitative analysis of biological samples. The pharmacokinetic results demonstrated that the combined administration of ABS and GE (60 mg·kg −1 + 60 mg·kg −1) could increase the degree of GE in joint cavity distribution, and the AUC joint/AUC plasm were twice of that of single administration of GE (60 mg·kg −1), which indicated that ABS might played a vital role in GE’s distribution to joint cavity. Moreover, there was no significant difference between the distribution trend of total three ABS and GE in rats. The pharmacodynamics results showed that the combined administration of ABS and GE had stronger effects on paw swelling, arthritis index and synovial pathomorphology of AA rats than single administration of GE, which suggested that ABS might improve GE’s anti-inflammatory effect in AA rats. Based on the above results, ABS has a targeting effect in increasing GE’s concentration in joint cavity, with a synergy in efficacy.

Study on wavelength overlapping HPLC fingerprint and multi-component content determination of Radix Salviae Miltiorrhizae

WANG Tao;ZHANG Hui;ZHAO Dan;CHEN Jie;XIE Zhuo-lin;DAI Wei;YE Kun-hao;HUANG Jing;CHEN Gang-fu

China Journal of Chinese Materia Medica,2019,Vol 44,No. 02

Cloning and function analysis of promoter of DcCDPK8 from Dendrobium catenatum

WANG Yuan;GAO Yan-hui;ZHU Yu-qiu;SI Jin-ping

China Journal of Chinese Materia Medica,2019,Vol 44,No. 02