Sponsor(s): Institute of Chinese Pharmaceutical Association
24 issues per year
Current Issue: Issue 24, 2019
Journal official website:http://zgzye.cbpt.cnki.net/WKE/WebPublication/index.aspx?mid=zgzye
China Journal of Chinese Materia Medica, the 1st in the field of TCM, is supervised by China Association for Science and Technology and sponsored by Institute of Chinese Pharmaceutical Association. The journal is China's earliest comprehensive core journal of traditional Chinese medicine, and always maintains the circulation top in the professional areas. The journal publishes the latest research and progress of traditional Chinese medicine and takes a leading position in numbers of articles published, downloads and citations among all journals in this discipline. Its scope covers new achievements, technologies, methods, experiences and concepts resulting from the research on Chinese materia medica pursuant to Chinese medical and pharmaceutical theories, traditional experiences, and modern science and technology, including medicinal resources and identification, cultivation, processing, preparation, chemistry, pharmacology, theory of Chinese pharmacy and clinical practice, bencaological study. The journal is included in CA, JST and CSCD.
Zhang Boli, Hu Zhibi, Yao Xinsheng, Li Lianda, Li Dapeng, Yang Baofeng, Zhou Chaofan, Huang Luqi, Chen Shilin, Li He.
Executive Editorial Board
Cai Shaoqing, Chen Shilin
China Journal of Chinese Materia Medica,2019,Vol 44,No. 24
The study aimed to investigate the effect of processing on lectin protein in four toxic Chinese medicines tubers of Pinellia ternata, P. pedatisecta, Arisema heterophyllum and Typhonium giganteum. Western blot was used to semi-quantitatively analyze the contents of lectins in the four kinds of toxic Chinese medicines and their different processed products. Raw products and lectin were treated by heating or soaking in ginger juice or alum solution. The effects of different excipients and the heating methods on lectin proteins were investigated. The results showed that the contents of lectins in the raw products of P. pedatisecta, P. ternata, A. heterophyllum, and T. giganteum were 7.3%, 4.9%, 2.7%, 2.3%, respectively. The content of lectin in Pinelliae Rhizoma Praeparatum cum Alumine was 0. 027%. Lectin was not detected in the Pinelliae Rhizoma Praeparatum cum Zingibere et Alumine, Arisaematis Rhizma Praeparatum and Typhonii Rhizoma Praeparatum, which indicated that processing could significantly reduce the contents of active lectins in raw products. The results also showed that with the prolongation of soaking and heating time, the contents of lectins in raw products decreased gradually, while the content was almost unchanged when soaked in ginger juice alone. The effects of different excipients and heating on lectin were the same as those on raw products. Therefore, the method with alum soaking and heating can reduce the contents of active lectins, which is the key to reduce the toxicity of toxic Chinese medicines. In this paper, Western blot was used to study the content of toxic proteins in Araceae toxic Chinese medicines as an evaluation method of the processing degree.