China Journal of Chinese Materia Medica, the 1st in the field of TCM, is supervised by China Association for Science and Technology and sponsored by Institute of Chinese Pharmaceutical Association. The journal is China's earliest comprehensive core journal of traditional Chinese medicine, and always maintains the circulation top in the professional areas. The journal publishes the latest research and progress of traditional Chinese medicine and takes a leading position in numbers of articles published, downloads and citations among all journals in this discipline.
Its scope covers new achievements, technologies, methods, experiences and concepts resulting from the research on Chinese materia medica pursuant to Chinese medical and pharmaceutical theories, traditional experiences, and modern science and technology, including medicinal resources and identification, cultivation, processing, preparation, chemistry, pharmacology, theory of Chinese pharmacy and clinical practice, bencaological study.
The journal is included in CA, JST and CSCD.
Honorary Editor-in-Chief Xiao Peigen Editor-in-Chief Wang Yongyan
Associate Editors Zhang Boli, Hu Zhibi, Yao Xinsheng, Li Lianda, Li Dapeng, Yang Baofeng, Zhou Chaofan, Huang Luqi, Chen Shilin, Li He.
Executive Editorial Board Cai Shaoqing, Chen Shilin
To explore the drug-induced constituents in vivo of
Polygonum multiflorum extract (PM). This study was the first to study the drug-induced constituents in target organ liver. Agilent MassHunter qualitative analysis software and Metabolite ID software were applied for the analysis of retention time, exact relative molecular mass, primary and secondary mass spectrum information based on ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and targeted-MS/MS. By comparison with literature and standards, a total of 5 prototypes and 6 metabolites were identified or tentatively elucidated from the liver samples. In addition, the drug-induced constituents in plasma and PM were also analyzed in this study and 8 prototypes and 19 metabolites were detected from the plasma samples, while 30 compounds were detected from the extract of PM. Emodin oxidative acetylation metabolites, hydroxyl methylation metabolites, carboxylation glucuronidation metabolites and ketone glucuronidation metabolites in this study were first reported. Through the comparative analysis between the in vivo and in vitro constituents of PM, the study preliminarily revealed the drug-induced constituents (prototypes and metabolites) in liver and clarified the transfer process and transmutation rules of constituents in PM, blood and liver, which would further deepen our understanding on constituents of PM in vivo.
The aim of this study was to investigate the renal toxicity of rhubarb and its mechanism. The SD rats were randomly divided into three groups: normal group and two rhubarb extract groups (16, 2 g·kg
−1). According to the dose conversion method between human and animal, rhubarb 16 g·kg
−1 and 2 g·kg
−1 were equivalent to 10 times and 1.25 times of human clinical dose respectively. Rhubarb extract was administered by a gastric gavage to rats once daily for 30 days. Serum urea nitrogen (BUN), creatinine (CRE) and urine KIM-1, NGAL and renal morphology were analyzed. The expressions of OAT1, OAT3 and clusterin mRNA in kidney were measured. The results showed that the low dose of rhubarb had no obvious renal toxicity. The high dose group showed mild and moderate renal injury and a down-regulation of clusterin mRNA expression in the kidney tissue. The renal toxicity in male animals was heavier than that in female animals. There was no significant change in blood BUN and CRE in the high dose group. But urine NGAL level of the high dose group increased by 51.53% compared with normal group, of which male animals increased more significantly (
P < 0.05, compared with the normal group). The expressions of renal OAT1 and OAT3 mRNA in the low dose group were obviously higher than that in the normal group. The results indicated that the high dose of rhubarb could cause the renal toxicity. The dosage should be controlled reasonably in the clinical use. OAT1 and OAT3 mRNA related to anionic transport in kidney tissue played a compensatory protective role in rhubarb-induced renal injury. But the compensatory effect is relatively weak at the high dose level. In addition, routine renal function indicators BUN and CRE had limitation for monitoring the kidney toxicity of rhubarb. It is suggested that urine NGAL detection might be helpful for monitoring the renal toxicity of rhubarb.
To investigate the effects of anti-androgen drugs and melengestrol acetate (MGA) on development of regrowth antlers in six-year-old sika deer, twenty healthy sika deer with similar body weight and antler weight were randomly divided into five groups by using single factor test design: flutamide (
n = 4), bicalutamide (
n = 4), progesterone acetate (CPA,
n = 4), MGA (MGA,
n = 4), control (
n = 4). All deer were fed with same diets and were housed outside together in an opened fence of 15 m × 30 m with free access to water and feed. Treatment groups were injected subcutaneously sustained-release agents of the four drugs respectively when two-branched antlers were harvested. The control group had no special treatment. In the experiment period of 60 d, blood samples were collected for four times for each deer. The concentration of testosterone in plasma was tested and analyzed to compare the changes between different groups. Development of regrowth antlers was observed. At the end of the experiment, regrowth antlers were weighted and analyzed. The results showed that the weights of regrowth antlers in treatment groups were significantly greater than those from control group and the weight gain (as compared with the control group) was 100.50%, 64.46%, 87.16%, and 117.46%, respectively, in flutamide group, bicalutamide group, CPA group and MGA group. For plasma testosterone concentration, it was not significantly different in the early stage (in the first 35 d), but at the end of the experiment, it was significantly higher than that of earlier stage (
P < 0.01) in various groups. Testosterone concentration of flutamide treated group was significantly lower than that of the other groups (
P < 0.01), while the level in bicalutamide and MGA treated groups was significantly higher than that in other groups (
P < 0.01). The results showed that both anti-androgen drugs and MGA treatment promoted the development of regrowth antlers and increased the weight of regrowth antlers, whereas the effect was most significant by MGA treatment. From the morphological observation of the antlers, it was found that anti-androgen and MGA treatments prolonged the growth period of regrowth antlers through delaying the ossification of antlers. However, plasma testosterone concentration was not affected by the treatments.
To evaluate the clinical efficacy and safety of tripterygium glycosides (TG) in the treatment of henoch-schonlein purpura nephritis (HSPN). Seven English and Chinese databases (up to Nov. 9, 2017), were searched to collect the RCTs on TG for HSPN. Two researchers independently screened the literature according to inclusion criteria and exclusion criteria, extracted data, and evaluated the quality of the literature. After completion, cross-checking was performed and Meta-analysis was performed using RevMan 5.3 software. At the same time, different outcomes of the interventions were analyzed subgroupically. A total of 46 RCTs were included, with 1 659 in the experimental group and 1 596 in the control group. All the clinical studies showed a low quality. In terms of complete remission rate, the group with TG performed better than the group with conventional therapy or GC (RR = 1.82, 95% CI [1.39, 2.39]; RR = 2.03, 95% CI [1.37, 2.99]), the group with TG + GC performed better than the group with GC (RR = 1.46, 95%CI [1.32, 1.60]), and the group with CTX + GC performed better than the group with TG + GC (RR = 0.35, 95% CI [0.16, 0.75]). In terms of total effective rate, the group with TG performed better than the group with conventional therapy or GC (RR = 1.44, 95% CI [1.19, 1.74]; RR = 1.30, 95% CI [1.16, 1.46]), the group with TG + GC performed better than the group with GC (RR = 1.27, 95% CI [1.21, 1.34]), and the group with CTX + GC performed better than the group with TG + GC (RR = 0.60, 95% CI [0.43, 0.85]). No significant difference was found between the group with TG + GC and LEF + GC (RR = 0.68, 95% CI [0.30, 1.53]). In terms of urinary protein, urine occult blood negative time, the group with TG performed better than the group with conventional therapy (MD = −9.00, 95% CI [−11.99, −6.01]; MD = −12.00, 95% CI [−16.13, −7.87]), the group with TG + GC performed better than the group with GC (MD = −8.86, 95% CI [−10.08, −7.64]; MD = −16.24, 95% CI [−23.80, −8.67]). In terms of recurrence rate, the group with TG + GC was lower than the group with GC (RR = 0.13, 95% CI [0.06, 0.25]), but there were no significant difference between the group with TG and conventional therapy (RR = 0.43, 95%CI [0.15, 1.19]). In adverse reactions, the common adverse effects of TG were gastrointestinal discomfort, liver damage and leucopenia. TG for the treatment of HSPN can improve clinical efficacy, reduce recurrence, and the adverse reactions are relatively safe. Due to the generally low methodological quality of the included studies, which affected the accuracy and reliability of the result. Therefore, more high-quality, large samples and multi-center randomized controlled trials are necessary for further evidence.
