China Journal of Chinese Materia Medica, the 1st in the field of TCM, is supervised by China Association for Science and Technology and sponsored by Institute of Chinese Pharmaceutical Association. The journal is China's earliest comprehensive core journal of traditional Chinese medicine, and always maintains the circulation top in the professional areas. The journal publishes the latest research and progress of traditional Chinese medicine and takes a leading position in numbers of articles published, downloads and citations among all journals in this discipline.
Its scope covers new achievements, technologies, methods, experiences and concepts resulting from the research on Chinese materia medica pursuant to Chinese medical and pharmaceutical theories, traditional experiences, and modern science and technology, including medicinal resources and identification, cultivation, processing, preparation, chemistry, pharmacology, theory of Chinese pharmacy and clinical practice, bencaological study.
The journal is included in CA, JST and CSCD.
Honorary Editor-in-Chief Xiao Peigen Editor-in-Chief Wang Yongyan
Associate Editors Zhang Boli, Hu Zhibi, Yao Xinsheng, Li Lianda, Li Dapeng, Yang Baofeng, Zhou Chaofan, Huang Luqi, Chen Shilin, Li He.
Executive Editorial Board Cai Shaoqing, Chen Shilin
Clinical application evaluation research of Guidelines for the Diagnosis and Treatment of Common Diseases of Pediatrics in Traditional Chinese Medicine (TCM) intended to evaluate its quality level and clinical application. The questionnaire and prospective case survey methods were used to evaluate the applicability evaluation based on the clinician questionnaire and the application evaluation based on clinical case observation. In terms of the applicability evaluation, the familiarity with and utilization rate of the Guidelines among the doctors were 85.06%, and 62.76 %, respectively. According to classification of the professional title, the physicians with intermediate professional title were more familiar with the Guidelines and used it the most frequently, while those with primary professional title were less familiar with the Guidelines and used it less frequently. In the evaluation of quality level of the Guidelines, except for recuperation and prevention (70.80%) and other treatments (87.82%) with lower scores in rationality evaluation, other indicators all had proportions over 96%. The applicability of all items, except for “simplicity” had proportions of more than 91%. As for the comprehensive application evaluation, except for formula composition (88.43%), other treatments (67.96%), and recuperation and prevention (65.86%), other items such as contents related to treatment based on syndrome differentiation in the Guidelines had higher conformity proportions of over 96%. In terms of application effectiveness of the Guidelines with good results, safety had a proportion of 92.96%, followed by efficacy (99.89%) and economy (97.45%). The research shows that the quality of the Guidelines is good and basically applicable to pediatric clinical practice, which can be used as a standardized recommendation for diagnosis and treatment of common pediatric diseases. Still, a small part of the Guidelines is not applicable, which needs to be further consummated. The contents related to recuperation and prevention as well as other treatments in the Guidelines shall be given special attention during revision.
To evaluate the applicability and clinical application of Guidelines for Diagnosis and Treatment of Internal Diseases in Traditional Chinese Medicine (TCM), so as to provide the basis for revision of the Guidelines. This study was completed by the research and promotion base for TCM standardization. The methods of applicability evaluation and application evaluation were used in the study. The questionnaires were filled out to evaluate applicability of the Guidelines, including doctor’s familiarity with the Guidelines, the quality of the Guidelines, applicable conditions and clinical applications. The prospective case study analysis method was used to evaluate application of the Guidelines, including evaluation of clinical application compliance and application results (such as clinical effects, safety and economy). There were two parts in the guidelines, which were TCM guideline and Western medicine guideline. The results of applicability evaluation showed that there were no obvious differences between TCM guideline and Western medicine guideline in doctor’s familiarity with the guidelines (85.43%, and 84.57%) and the use of the guidelines (52.10%, and 54.47%). The guidelines with good quality, and higher scores in the scope of application and the use of the term rationality were 91.94%, and 93.35%, respectively. The rationality scores of relevant contents in syndrome differentiation and treatment were more than 75%. The applicable conditions were better, and the safety score was the highest. The comprehensive applicability evaluation showed that the proportions of the application of TCM guidelines and Western medicine guidelines were 77.73%, and 75.46%, respectively. The results of application evaluation showed that there was a high degree coincidence between the guidelines and its clinical application; Except for “other treatments” and “recuperation and prevention” in TCM, other items got high scores which were more than 90%. In the evaluation of application effects, the safety of the guidelines was the best, the economy of the guidelines was better, and the clinical effect was good. The comprehensive application evaluation showed that 75%–80% of doctors were satisfied with the Guidelines. The Guidelines for Diagnosis and Treatment of Internal Diseases in TCM has been widely used in clinical practice, which is of high quality, high degree of clinical application, good safety and economy. But there are some disadvantages of the Guidelines such as lack of evidence-based medicine method and innovation, which needs to be improved constantly in the revision of the Guidelines.
Based on the reviewing of development and disadvantages of Chinese medicine formula granules, the concept of standard decoction of traditional Chinese medicine was proposed in this study, and it was used as the standard mode of Chinese medicine formula granules to standardize the production process and quality standards of formula granules. The standard was unified according to the principles of “standardization of medicinal materials, standardization of process, intellectualization of production, standardization of quality, normalization of packaging, and informatization of storage”; and consistency evaluation was carried out by the analysis of chemical components, pharmacological activities and clinical efficacy of the standardized decoction and the traditional decoction, interpreting the scientific questions to ensure the stability and uniformity of Chinese medicine formula granule as well as the safety and effectiveness of its clinical application.
We carried out the investigation on a sponge-derived fungus, which was identified as Emericella variecolor from the South China Sea. Two new chemical constituents, (+)-2-acetyl-dihydroterrein (1) and (+)-3-acetyl-dihydroterrein (2), with four known constituents, anditomin (3), andilesin A (4), andilesin C (5) and andilesin B (6), were isolated from this fungus by column chromatography over silica gel, Sephadex LH-20, and ODS. The structures of 1 and 2 were elucidated by spectroscopic methods including NMR, HR-ESI-MS, and CD.
Ligusticum chuanxiong is a well-known traditional Chinese medicinal plant. In this study, we obtained 24 422 unigenes of L. chuanxiong by assembling transcriptome sequencing reads of L. chuanxiong. EST-SSR was detected and 4 073 SSR loci were identified. The EST-SSR distribution and characteristic analysis results showed that the mononucleotide repeats were the main type of the nucleotide repeats, accounting for 41.0% of the unigenes. In addition, the sequences containing SSR were functionally annotated in Gene Ontology (GO) and KEGG pathway and were assigned to 49 GO categories, 242 KEGG pathways, among which 2 201 sequences were annotated according to Nr database. By validating 235 EST-SSRs, 74 primer pairs were shown to generate high-quality products. Subsequently, genetic diversity analysis, UPGMA cluster analysis, PCoA analysis and population structure analysis of 34 L. chuanxiong germplasm resources were carried out with 74 pairs of primers. According to the results of UPGMA tree and PCoA analyses, the L. chuanxiong resources were clustered into two groups, which were believed to be partially related to their geographical distribution. In this study, the EST-SSRs in L. chuanxiong was firstly identified, and newly developed molecular markers would significantly contribute to further study on genetic diversity, strain purity detection, gene mapping, and molecular breeding.
With lubricant and bonding effect simultaneously, wetting agent has direct effects on properties of wet materials and extrudate, thus affecting the forming quality of pellets in extrusion-spheronization process. In this research, 25 representative kinds of traditional Chinese medicine (TCM) were selected as model drugs and 20%, 30% and 40% drug loading were set with MCC as their balling agent. The torque rheological curves were measured to get parameters such as maximum torque (
Tmax) and corresponding water addition (
W
Tmax) for these 75 raw materials by a mixer torque rheometer (MTR). The results showed that among 75 representative raw materials, 74 could be obtained for spherical pellets under the water addition of
W
Tmax-2. The second largest torque in torque rheological curve indicated that MTR could be used to select the optimal wetting agent dosage of TCM pellets. So the tedious and expensive pre-production work could be considerably reduced when TCM pellets were prepared.
For thousands of years, scorpions and their venoms have been applied in traditional medicine in China to treat a variety of difficult miscellaneous diseases. The venom is a complex mixture of bioactive molecules, such as peptides and proteins (e.g. neurotoxins). Among them, neurotoxins (named scorpion toxins) are the most important bioactive components. Up to now, more and more characterized venom components have been isolated from different scorpions, providing numerous candidate molecules for drug design and development. Many investigations have shown the potent effects of venom or its components against the nervous, immune, infection, cardiovascular and neoplastic diseases. Moreover, the scorpion toxins could be used as molecular backbone to develop new specific drugs based on their unique structures and functions. In this review, we focus on the medicinal values and the possible mechanisms of scorpion toxins with promising medicinal prospect against the relative diseases, providing the data basis for further development of relative drugs.
Cucurbitadienol has anti-inflammation and anti-cancer activities, and it acts as a precursor of bioactive ingredients of traditional Chinese medicine including mogroside and cucurbitacine. To construct a
Sacchromyces cerevisiae cell factory for high-level production of cucurbitadienol, we firstly cloned a cucurbitadienol synthase (CBS) gene from
Siraitia grosvenorii. Then, through heterologous expression of CBS in the triterpenoid chassis strain WD-2091, the engineered strain reached a yield of 27.44 mg·L
−1 cucurbitadienol. Further regulation of CBS expression led to an increased cucurbitadienol yield by 202.07%, reaching 82.89 mg·L
−1 in the flask fermentation and 1 724.10 mg·L
−1 in high-density fermentation. Our research promoted the elucidation of cucurbitane-type tetracyclic triterpenoids synthesis pathway and provided basis for further construction of cell factories producing cucurbitadienol-type tetracyclic triterpenoids.
