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Brief

China Journal of Chinese Materia Medica, the 1st in the field of TCM, is supervised by China Association for Science and Technology and sponsored by Institute of Chinese Pharmaceutical Association. The journal is China's earliest comprehensive core journal of traditional Chinese medicine, and always maintains the circulation top in the professional areas. The journal publishes the latest research and progress of traditional Chinese medicine and takes a leading position in numbers of articles published, downloads and citations among all journals in this discipline. Its scope covers new achievements, technologies, methods, experiences and concepts resulting from the research on Chinese materia medica pursuant to Chinese medical and pharmaceutical theories, traditional experiences, and modern science and technology, including medicinal resources and identification, cultivation, processing, preparation, chemistry, pharmacology, theory of Chinese pharmacy and clinical practice, bencaological study. The journal is included in CA, JST and CSCD.
Editorial Board

Honorary Editor-in-Chief
Xiao Peigen
Editor-in-Chief
Wang Yongyan

Associate Editors
Zhang Boli, Hu Zhibi, Yao Xinsheng, Li Lianda, Li Dapeng, Yang Baofeng, Zhou Chaofan, Huang Luqi, Chen Shilin, Li He.

Executive Editorial Board
Cai Shaoqing, Chen Shilin

Effects and mechanisms of Shenkang injection promoting extracellular matrix degradation via regulating ERK1/2/MMPs signaling pathway in renal failure rats

YANG Jing-jing;MAO Zhi-min;WAN Yi-gang;WU Wei;HUANG Yan-ru;SHI Ge;HAN Wen-bei;YAO Jian

China Journal of Chinese Materia Medica,2016,Vol 41,No. 20

This study aimed to preliminarily clarify the effects and mechanisms of Shenkang injection (SKI) promoting extracellular matrix (ECM) degradation via regulating extracellular-signal regulated protein kinase (ERK) 1 /2 / matrix metalloproteinases (MMPs) signaling pathway in renal failure rats. Twenty rats were randomly divided into 4 groups: the Sham operation group, the model group, the SKI group and the Enalapril maleate (EM) group. The model rats with renal failure were induced by adenine gavage combined with unilateral ureteral obstruction (UUO). After modeling, the rats in SKI group and EM group were received intraperitoneal injection of SKI or EM suspension gavage, while the rats in Sham operation group and model group were fed with distilled water respectively for 3 weeks. The 24 h urinary protein excretion (Upro) and urinary N-acety1-β-D-glucosaminidase (UNAG) in all rats were tested after drug administration. All rats were killed after drug administration for 3 weeks, blood and kidney were collected, and renal morphological characteristics were observed. Furthermore, serum biochemical indicators and the protein expressions of collagen type IV(CIV), MMP-2, MMP-9, tissue inhibitors of metalloproteinase (TIMP)-1, ERK 1 / 2 and phosphorylated-ERK 1 / 2 (p-ERK 1 / 2) in the kidney were evaluated respectively. The results indicated that, after the intervention of SKI, serum creatinine (Scr), blood urea nitrogen (BUN), uric acid (UA), albumin (Alb), Upro, UNAG and renal morphological changes in model rats were improved at different levels, respectively. Moreover, these effects were similar to EM. In addition, SKI regulated the protein expressions of MMP-2, MMP-9 and TIMP-1, and down-regulated the protein expressions of p-ERK1 /2 in the kidney. Moreover, these effects were different from EM. In conclusion, SKI promoted ECM degradation and delayed the progression of renal failure possibly through regulating ERK1 /2 signaling pathway activation in the kidney and intervening MMPs / TIMP-1 expressions in vivo.

Effects of arbuscular mycorrhizal fungi on endogenous hormones in Salvia miltiorrhiza

ZHOU Xiu-teng;WANG Xue;YANG Guang;CHEN Min;LI Peng-ying;HUA Guo-dong;CHEN Mei-lan;GUO Jiao

China Journal of Chinese Materia Medica,2016,Vol 41,No. 20

Chemical studieson hydrophilic constituents of toad skin

XIN Shao-kun;SI Nan;WANG Hong-jie;YANG Jian;GAO Bo;WEI Xiao-lu;ZHAO Hai-yu;BIAN Bao-lin

China Journal of Chinese Materia Medica,2016,Vol 41,No. 20