Sponsor(s):China Association for Acupuncture and Moxibustion;Acupuncture Institute of China, Academy of Traditional Chinese Medicine
12 issues per year
Current Issue: Issue 11, 2020
Chinese Acupuncture & Moxibustion is supervised by China Association for Science and Technology and sponsored by China Association for Acupuncture and Moxibustion, Acupuncture Institute of China and Academy of Traditional Chinese Medicine. The journal is a comprehensive journal of acupuncture and moxibustion in China, which embraces a high level editorial board domestically and overseas. The scope of this journal covers the acupuncture and moxibustion clinical researches, experts’ experience, meridian and acupoint studies, mechanisms, teaching methods, studies on literature. In China, this journal is with a wide range of readers and a group of high-level authors. It has won the first and second rewards many times in all the national competitions of excellent periodicals of traditional Chinese medicine sponsored by the State Administration of Traditional Chinese Medicine and has been subsidized by the high-quality sci-tech periodical project of China Association for Science and Technology several times. The journal is included in CA, JST and CSCD.
YU Xiaochun JING Xianghong
Deng Liangyue, Shi Xuemin, Sun Guojie, Li Weiheng, Chen Hanping, He Puren, Cheng Shennong
Wang Zhihong, W
Effect of Tongdu Tiaoshen acupuncture on PI3K/Akt/mTOR signaling pathway and autophagy-related proteins of hippocampus in rats with post-stroke depression
Chinese Acupuncture & Moxibustion,2020,Vol 40,No. 11
Objective To observe the effects of Tongdu Tiaoshen acupuncture on depression-like behavior in rats with post-stroke depression (PSD), and to explore its possible mechanism. Methods A total of 48 SD rats were randomized into a sham-operation group, a model group, a Tongdu Tiaoshen group and a non-meridian-non-acupoint group, with 12 rats in each group. In the model group, the Tongdu Tiaoshen group and the non-meridian-non-acupoint group, PSD model was established using the compound method of cerebral medial arterial occlusion, chronic unpredictable mild stress and isolation. Acupuncture was applied at “Dazhui” (GV 14), “Shuigou” (GV 26), “Baihui” (GV 20) and “Shenting” (GV 24) in the Tongdu Tiaoshen group, and at the bilateral dorsum hollows between 3rd and 4th metatarsal bones of the forelegs in the non-meridian-non-acupoint group. The needles were retained for 40 min in both groups, and the treatment was performed once a day, 6 times a week, for 4 weeks. Before model establishment and after intervention, the Zea Longa neurological behavioral score, open-field test and sucrose preference test were evaluated in the 4 groups. The levels of phosphatidylinositol 3-kinase (PI3K), phosphorylated protein kinase B (p-Akt), phosphorylated mammalian target of rapamycin (p-mTOR), Beclin1 and LC3B-Ⅱ/Ⅰ in the CA1 region of the hippocampus were detected by western blot assay. The mRNA expression levels of Beclin1, and LC3B-Ⅱ in the CA1 region of hippocampus were detected by real-time PCR. Results After model establishment, compared with the sham-operation group, the Zea Longa neurological behavioral scores were increased ( P < 0.05); the horizontal and vertical motion scores in the open-field test and the sucrose water consumption were decreased in the model group, the Tongdu Tiaoshen group and the non-meridian-non-acupoint group ( P < 0.05). After intervention, compared with the sham-operation group, the Zea Longa neurological behavioral score and the expression levels of Beclin1, LC3B-Ⅱ/Ⅰ and LC3B-Ⅱ in the CA1 region of hippocampus were increased ( P < 0.05); the horizontal and vertical motion scores in the open-field test, the sucrose water consumption and the expression levels of PI3K, p-Akt and p-mTOR were decreased in the model group ( P < 0.05). After intervention, compared with the model group and the non-meridian-non-acupoint group, the Zea Longa neurological behavioral score and the expression levels of Beclin1, LC3B-Ⅱ/Ⅰ and LC3B-Ⅱ in the CA1 region of hippocampus were decreased ( P < 0.05); the horizontal and vertical motion scores of the open-field test, the sucrose water consumption and the expression levels of PI3K, p-Akt and p-mTOR were increased in the Tongdu Tiaoshen group ( P < 0.05). Conclusion Tongdu Tiaoshen acupuncture can effectively improve the depression-like behavior in PSD rats, which is related to the activation of PI3K/Akt/mTOR signaling pathway and the inhibition of hippocampal neuron autophagy.
Clinical observation on distribution characteristics and rules of pain sensitivity points on body surface in patients with knee osteoarthritis
Chinese Acupuncture & Moxibustion,2020,Vol 40,No. 11
Objective To observe the distribution characteristics and rules of pain sensitivity points on the body surface in patients with knee osteoarthritis (KOA). Methods A total of 916 patients with KOA were selected in this study, and the pain sensitivity points at the local site of the knee joint were probed by thumb palpation. The tape was used to measure the distance between the pain sensitivity points and the most nearby acupoints. The Wagner tenderness measuring instrument was used to measure the tenderness threshold of pain sensitivity points. Results A total of 3618 pain sensitivity points were probed, among which 3338 pain sensitivity points were sensitized. The minimum sensitization degree was 1.00 and the maximum sensitization degree was 3.39, with an average sensitization degree of (2.16 ± 0.60). Pain sensitivity points were distributed 0.37–1.73 cun around the acupoints, with an average distance of (1.26 ± 0.20) cun. Most of the pain sensitivity points (48.7%) were around Yingu (KI10), Ququan (LR8), and Xuehai (SP10). The number and sensitization degree of pain sensitivity points were associated with the McGill pain questionnaire score of patients with KOA ( P < 0.001). Conclusion The pain sensitivity points of patients with KOA may result from the expansion effect of acupoint areas in the disease states, and pain sensitivity points are more likely to appear on the medial side of the knee joint.