Sponsor(s): Tianjin Institute of Pharmaceutical Research；Chinese Pharmaceutical Association
24 issues per year
Current Issue: Issue 13, 2015
Chinese Traditional and Herbal Drugs is supervised by Chinese Pharmaceutical Association and sponsored by Tianjin Institute of Pharmaceutical Research and Chinese Pharmaceutical Association. Launched in 1970, the journal is an academic journal with a broad scope in publishing research papers, brief reports, reviews, dissertations, and special treatises on the recent achievements of basic study, production, quality control, and clinic application on traditional Chinese medicine and Chinese materia medica. The journal is included in CA, JST and CSCD.
Chinese Traditional and Herbal Drugs,2015,Vol 46,No. 13
Objective To study the effect of ultrafine grinding on the micromeritic properties of Zhengfupian (steamed pieces of Aconiti Lateralis Radix Praeparata) and provide the basis for its preparation and quality control. Methods Three kinds of Zhengfupian powders were prepared by ultrafine grinding mill. Their micromeritic properties, including size distribution, surface area and porosity, flowability, scanning electronic microscope, infrared spectrum, moisture absorption and dissolution rate were detected. Then, the effects were comprehensively analyzed. Results With the increase of grinding time, the powder’s particle size decreased; the morphology and structure tended to be uniform; the specific surface area and porosity increased; the particles assembled easily; the compressibility and the angle of repose increased; the dissolution rate increased dramatically, and there were no significant changes in the infrared spectrum and moisture absorption. Conclusion As the micromeritic properties and dissolution rate of Zhengfupian are considered, Zhengfupian’s ultrafine grinding time should be controlled at about 25 min, the particle size d0.9 should be around 100.46 μm.