Sponsor(s): Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences; China Association of Acupuncture-Moxibustion
6 issues per year
Current Issue: Issue 12, 2020
Journal official website:http://xcyj.cbpt.cnki.net/WKA3/WebPublication/index.aspx?mid=xcyj
Acupuncture Research, the only journal in China that focus on the mechanism of acupuncture and moxibustion, is supervised by State Administration of Traditional Chinese Medicine of the People's Republic of China and sponsored by Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences and China Association of Acupuncture-Moxibustion. Launched in 1976, the journal is a sole academic journal mainly reporting the original experimental studies about the mechanism of the effects of acupuncture and moxibustion for treating common diseases. About 75% of these studies are subsidized by Chinese National Natural Science Foundation, Ministry of Science and Technology, Ministry of Education, State Administration of TCM, provincial (municipal) natural science foundation. The articles published in this journal no doubt reflect the highest level of scientific research in the field of acupuncturology in China. It is titled as the “Outstanding Scientific and Technological Journal of China” and “RCCSE Authoritative Academic Journal of China.” The journal is included in CA, CSCD.
Members of Editorial Board
Christopher John Zaslawski (Australia) CUI Jin(China)
DENG Liangyue(China) DING Guanghong(China)
DONG Guirong(China) FAN Yushan(China)
Effect of electroacupuncture preconditioning on cell apoptosis mediated by mitochondrial reactive oxygen species in myocardial ischemia/reperfusion injury rats
Acupuncture Research,2020,Vol 45,No. 12
Objective To observe the effect of electroacupuncture (EA) preconditioning on cell apoptosis and the content of mitochondrial reactive oxygen species (ROS) in rats with myocardial ischemia/reperfusion injury (MIRI), so as to explore their mechanisms underlying the improvement of MIRI. Methods Eighty male Wistar rats were randomly divided into the normal, sham operation, ischemia reperfusion and EA groups, with 20 rats in each group. Rats of the normal, sham operation, ischemia reperfusion and EA groups were just fixed for 30 min, once daily for 7 days. Before modeling, EA (2 Hz, 1 mA) was applied to Neiguan (PC6), Zusanli (ST36), Guanyuan (CV4) for 20 min, once daily for 7 successive days in the EA group. The MIRI model was established by occlusion of the left anterior descending branch of the left coronary artery for 20 min, followed by reperfusion for 30 min. Ventricular arrhythmia (VA) score was used to evaluate arrhythmia. Enzyme-linked immunosorbent assay (ELISA) was used to detect the level of CK-MB. DHE staining was used to detect the content of reactive oxygen species (ROS). The gene expression levels of cytochrome C (Cyt-C), Caspase-9 and Caspase-3 were detected by real-time fluorescent quantitative PCR. Results Compared with the sham group, the VA score, serum CK-MB content, ROS content in heart tissue and gene expression levels of Cyt-C, Caspase-9 and Caspase-3 were significantly up-regulated in the MIRI group (all P < 0.01). Following the intervention, the increased VA score, serum CK-MB content, ROS content in heart tissue, as well as gene expression levels of Cyt-C, Caspase-9 and Caspase-3 were all reversed in the EA group as compared with those in the MIRI group (all P < 0.01). Conclusion The protective effect of EA preconditioning on MIRI may be related to the regulation of ROS mediated-apoptosis pathway.