Sponsor(s): Chengdu Library and Information Center, Chinese Academy of Sciences
12 issues per year
Current Issue: Issue 08, 2020
It aims to report the latest achievements in natural product research, develop a wide range of uses for natural product research, promote academic exchanges at home and abroad, strengthen the process of scientific research, development and production, and spread strategic, forward-looking and innovative scientific and technological achievements to promote the development of China's technology and economic.
Editor-in-Chief: Li Bogang
Preventive effects of chitooligosaccharides on dextran sulfate sodium-induced ulcerative colitis in mice
Natural Product Research and Development,2020,Vol 32,No. 08
The aim of our study was to investigate the protective effect of chitooligosaccharides (COSs) on mice with dextran sulfate sodium (DSS)-induced ulcerative colitis, which is expected to provide a theoretical reference for the development and utilization of COS. In this study, ulcerative colitis was induced by oral administration of 3% DSS in drinking water for seven days. A total of 50 male C57 BL/6 mice were randomly classified into five groups: control group, model group, positive control group with sulfasalazine (SASP, 50 mg/kg), low-dose COS group (70 mg/kg) and the high-dose COS group (140 mg/kg). The protective effect of COS was assessed via weight change, disease activity index (DAI), colon length, histopathological score, and myeloperoxidase (MPO). The inflammatory cytokines in colon tissue were detected by ELISA. COS supplement decreased the weight loss, DAI, and MPO activity ( P > 0.05), also significantly reduced the levels of interleukin (IL)-6 and tumor necrosis factor (TNF)- α in the colon tissue in DSS-treated mice ( P < 0.05). In addition, 70 mg/kg COS showed significant protective effect on the colon length and colonic structure in response to DSS challenge ( P < 0.01), which was better than that of 140 mg/kg COS. In conclusion, COS (70 mg/kg, transformed from a recommended dosage of human) showed obvious protective effects against DSS-induced colitis, which may be associated with suppressed neutrophil infiltration and inflammation.