Sponsor(s): Chinese Society for Microbiology
6 issues per year
Current Issue: Issue 06, 2020
Chinese Journal of Virology, an academic periodical established in 1985, publishes Original Articles, Brief Reports, Reviews, and so on, covering the advances and achievements of fundamental and applied research concerning human, animal, plant, and insect viruses as well as bacteriophages and prions. The subscribers of Chinese Journal of Virology are mainly workers in research institutes, universities, and other institutions of virological and biological studies in China, as well as world-known databases and libraries. Chinese Journal of Virology is supervised by the China Association for Science and Technology, sponsored by the Chinese Society for Microbiology, run by the National Institute for Viral Disease Control and Prevention, China CDC, and published by its Editorial Office. The International Standard Serial Number is ISSN 1000-8721; the Domestic Journal Number is CN 11-1865/R; the Domestic Postal Distribution Code is 82-227 (domestically distributed by all local post offices in China); the Overseas Distribution Code is BM6448 (distributed by China International Book Trading Corporation). Chinese Journal of Virology has been published bimonthly since 2005 and is now distributed worldwide. Chinese Journal of Virology is included in the Outstanding S&T Journals of China, Chinese Core Journals of Science and Technology, A Guide to the Core Journals of China (published by Peking University), Research Center for Chinese Science Evaluation, Wuhan University, and Chinese Science Citation Database source journals. In addition, it is indexed in CA, BA, CBST, MEDLINE (PubMed), and WPRIM. Chinese Journal of Virology has been included in the databases of CNKI (Disc Edition) since December 30, 2008. It began to tentatively offer Advance Online Publication in 2009 and has been formally offering Advance Online Publication since 2011. The composite impact factor of Chinese Journal of Virology is 1.355, according to the Annual Report for Chinese Academic Journal Impact Factors (Basic Medical Sciences) (2015, Volume 13), ranking top among the journals of basic medical and biological sciences. The homepage of Chinese Journal of Virology on CNKI is http://bdxb.cbpt.cnki.net. Chinese Journal of Virology started a pilot program of bilingual publication on November 8, 2016 to publish papers in both Chinese and English on CNKI net.
Honorary Editor-in-Chief: HOU Yunde
Editor-in-Chief: SHU Yuelong
LIU Xiufan, FANG Rongxiang, WU Guizhen, JIN Qi, LIANG Mifang, LI Mengfeng, XIA Ningshao, TAN Wenjie, XU Wenbo, WANG Yumei
Characteristics of SARS-CoV-2 Nucleic Acids and Serum Antibodies in Different Clinical Specimens and Their Correlation with the Course of COVID-19
Chinese Journal of Virology,2020,Vol 36,No. 06
To investigate the characteristics of the nucleic acids of severe acute respiratory syndrome coronavirus (SARS-CoV-2) and antibodies in different specimens obtained from patients with coronavirus disease 2019 (COVID-19) and whether a correlation between these parameters and the disease course was present. The throat swabs and stool samples of 39 COVID-19 patients admitted to our hospital were collected in this study. Real-time reverse transcription-quantitative polymerase chain reaction (RT-PCR) was undertaken on throat swabs and stool samples. Peripheral blood was taken and the serum levels of IgM and IgG were measured. The results showed that throat swabs and stool samples tested positive for the nucleic acid of SARS-CoV-2, while the nucleic acid levels reduced significantly and the Ct value of the nucleic acid test increased significantly 15 days after disease onset compared with that upon diagnosis. The serum levels of IgM and IgG in patients were significantly higher than those in healthy people. Nucleic acid loads in throat swabs and stool samples as well as serum levels of IgM and IgG were highly correlated with the disease course ( r = 0.738 7, 0.569 6, −0.546, and 0.611 7, respectively, P < 0.05). In this study, the nucleic acid loads in throat swabs and stool samples, as well as serum levels of IgM and IgG, were highly correlated with the course of COVID-19.