Publisher(s): China Academic Journals (CD Edition) Electronic Publishing House Co., Ltd.
ISBN: ISBN 978-7-499-00978-3 pdf
First Published: 2020.11.23
Discipline(s): Medicine & Public Health
Price: $109 (for individuals) (中国大陆地区个人用户点此直接购买)
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Inflammation, as part of China’s Medicine Progress Series, has 76 excellent articles on inflammation research. These articles included were recommended by the editorial boards of the journals in which they were originally published, covering theoretical, drug, mechanism, clinical, and nursing research and fully demonstrating the cutting-edge advances in inflammation treatment in China, with methodological support and objective conclusions. The original articles are published in Chinese, and this book is a compilation of English versions of selected articles.
LIU Changxiao is the honorary president, tenured principal scientist and academic committee director of Tianjin Institute of Pharmaceutical Research, and the director of the State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, the Center
1. Network pharmacology-based study on mechanisms of Huanglian Jiedu Decoction impact on macrophage inflammation response
Acta Pharmaceutica Sinica,Part 1: Theoretical Analysis,Vol 53,No. 01
This study was designed to explore the impact of Huanglian Jiedu Decoction (HLJDT) on macrophage inflammation reaction using the network pharmacology method. Glycolysis, sphingolipid metabolism and glutamine metabolism were also investigated for “multi-component, multi-target and multi-pathway”, which supports a foundation for drug innovative research. The TCMSP database was used to screen the active components of HLJDT, the target protein predicted by Pharm Mapper database and the DAVID database for pathways annotation and analysis. The Cytoscape 3.2.1 software was used to construct the active component target–pathway network map and GENEMANIA database for protein interaction analysis. System Dock Database Site is used in verification of molecular docking. The results showed that 84 active ingredients were screened in HLJDT with a total of 111 target targets. Fourteen pathways are affected according to 13 macrophage-related inflammatory proteins, and 8 pathways including 34 target proteins from glycolysis, sphingolipid metabolism and glutamine metabolism. Inflammation-related proteins and metabolism-related proteins can interact with each other through physical correlation, protein co-expression, etc. Berberine, baicalin and geniposide combined well with 5 important targets. Huanglian Jiedu Decoction may act on the glycolysis and sphingolipid pathways to regulate macrophage inflammatory responses.
Acta Pharmaceutica Sinica,Part 1: Theoretical Analysis,Vol 53,No. 02
To investigate the anti-inflammatory mechanisms of taurochenodeoxycholic acid (TCDCA), the molecule structure file of TCDCA was downloaded from PubChem database, PharmMapper and GeneCards were used to predict and screen the targets of TCDCA. STRING database and Cytoscape software were used to construct protein interactions network. GO and KEGG analysis was preformed through STRING database. The key targets were validated by molecular docking and the targets type was attributed by DisGeNET database. The network showed that 89 targets were involved in 68 biological processes including response to stimulus, multicellular organismal process, single-multicellular organism process, response to chemical, response to organic substance, by adjusting 51 signaling pathways, such as pathways in cancer, progesterone-mediated oocyte maturation, MAPK signaling pathway, proteoglycans in cancer. These findings provide an overview of anti-inflammation of TCDCA, which reflects the characteristic of multi-targets and multi-pathways of TCDCA. It pointed out the direction for further research on anti-inflammatory mechanism of TCDCA.
3. Anti-inflammatory mechanism of main constituents in essential oil from Schizonepeta tenuifolia Briq. based on network pharmacology
Chinese Pharmacological Bulletin,Part 1: Theoretical Analysis,Vol 36,No. 03
Aim To explore the main components and anti-inflammatory mechanisms of essential oil from Schizonepeta tenuifolia Briq. based on network pharmacology. Methods TCMSP and Swiss Target Prediction were used to obtain the corresponding targets of molecules, and the active components were screened. The molecular-target network was constructed. Then, protein-protein interaction (PPI) analysis, GO analysis, and KEGG pathway analysis were performed. Finally, molecular docking by SystemsDock was combined with previous literature. Results According to the results of network analysis, 13 main components corresponding to 45 targets were screened out. IL6, TNF, IL1β, IL10, PTGS2, PTGS1, CHRM1, and CHRNA7 were important inflammatory targets through NF-κB and IL-17 signaling pathway. Biological processes such as response to drug, γ-aminobutyric acid pathway, and molecular functions such as extracellular ligand-gated ion channel activity, GABA-A receptor activity play a role in inflammation related to alcohol consumption, type 2 diabetes, psychiatric disorders, enteropathy, lung diseases, etc. 8,9-dehydrothymol, benzaldehyde, caryophyllene, α-humulene, D-germacrene, and pulegone were important anti-inflammatory components, exerting significant effects on CHRNA7, PTGS2 and PTGS1. Conclusion This method initially reveals the effective components and potential targets of essential oil from Schizonepeta tenuifolia Briq.
4. Identification based on HPLC and anti-inflammatory targets as well as related constituents analysis of Asarum heterotropoides var. mandshuricum and A. sieboldii
China Journal of Chinese Materia Medica,Part 1: Theoretical Analysis,Vol 45,No. 04
The present work is to establish the HPLC characteristic chromatograms of Asarum heterotropoides var. mandshuricum (AH) and A. sieboldii (AS), explore the identification method for the two species in combination with cluster analysis, and predict their potential anti-inflammatory related targets by network pharmacology. Eighty-nine samples (12 batches of AS and 77 batches of AH) were analyzed, and 11 characteristic peaks were identified by reference substances, UV spectrum and LC-MS. Cluster analysis showed that AS and AH were divided into two groups, and the ratio of characteristic peak areas could be used to distinguish them. When the area ratio of characteristic peak sarisan to kakuol was greater than five, it was AS, and when the ratio was less than two, it was AH. The network pharmacological analysis of 119 components of Herba Asari suggested that its anti-inflammatory effect might be related to COX-2, COX-1, iNOS, MAPK14, NR3C1, PPARG and TNF. Among them, COX-2 was a relatively key target, which interacted with the characteristic components: asarinin, sesamin, safrole, methyleugenol and sarisan. Asarinin and sesamin also interacted with iNOS and MAPK14. Safrole and sarisan could also interact with iNOS, COX-1 and LAT4H. Methyleugenol also showed interaction with COX-1 and LAT4 H. Since asarinin and sesamin interacted with three targets: COX-2, iNOS and MAPK14, it suggested that they were the main active components for the anti-inflammatory activity of Herba Asari. The COX-2 inhibitory activities of asarinin and sesamin were further studied by molecular docking and bioassay. The HPLC method established was simple, feasible and reliable, and the predicted anti-inflammatory targets and anti-inflammatory components could provide a reference for improving the quality evaluation system of Herba Asari.
5. Discussion on the application of Traditional Chinese Medicine with Antipyretic, Anti-inflammatory or Immunoregulatory in the treatment of COVID-19
Journal of Chinese Medicinal Materials,Part 1: Theoretical Analysis,No. 05
At the end of December 2019, the new coronavirus pneumonia (COVID-19) broke out in China. As of April 7, 2020, more than 1.5 million people have been infected in the world. At present, the epidemic situation in China has been basically controlled. There have been no new cases in many provinces and regions for many consecutive days. The deterioration of overseas epidemic conditions has led to an increasing in imported patients in China. The rational use of Chinese medicine has played a very active role in combating the epidemic of the new coronavirus pneumonia in China. According to the latest version of the “Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7)” and the effects of traditional Chinese medicine (TCM), we analyzed the potential application value of single Chinese medicine and Chinese medicine prescriptions against COVID-19-induced fever, inflammation, and immune imbalance, to provide a reference for clinical application of TCM for treatment of COIVD-19.