Publisher(s):China Academic Journals (CD Edition) Electronic Publishing House Co., Ltd.
ISBN:ISBN 978-7-499-00972-1 pdf
First Published: 2020.11.23
Discipline(s): Medicine & Public Health
Price: $79 (for individuals) (中国大陆地区个人用户点此直接购买)
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Depression, as part of China’s Medicine Progress Series, has 50 excellent articles on depression research. The articles included were recommended by the editorial boards of the journals in which they were originally published, covering theoretical, mechanism, clinical, and psychological research. These articles fully demonstrate the cutting-edge advances in depression treatment in China, with scientific methodological support and objective conclusions. The original articles were published in Chinese, and this book is a compilation of English versions of selected articles.
REN Zhihong, professor and doctoral supervisor, is engaged in the research of clinical and counseling psychology. He is an editorial board member of Acta Psychologica Sinica and a reviser for its English edition. Besides, he serves as a member of multiple
Chinese Archives of Traditional Chinese Medicine,Part 1: Theoretical Analysis,Vol 35,No. 01
Depressive disorder has become a serious social and medical problem. TCM believes that depressive disorder is closely related to the liver governing free flow of qi and regulating emotions. However, the scientific connotation of liver governing free flow of qi and regulating emotions is still unclear and there is a lack of objective evaluation method. The author thinks that research on the eye movement of depressive disorder patients can provide new ideas and methods to solve these problems. Research on recognition of depressive eye movement and internal mechanism of depressive eye movement has important scientific significance to the objective evaluation of depressive disorder and the revealing of the theoretical connotation of liver governing free flow of qi and regulating emotions.
Chinese Acupuncture & Moxibustion,Part 1: Theoretical Analysis,Vol 38,No. 02
3. Mechanism of Xiaoyao Powder in treating depression and diabetes from the perspective of “treating different diseases with the same method” based on network pharmacology
Chinese Traditional and Herbal Drugs,Part 1: Theoretical Analysis,Vol 50,No. 03
Objective In this paper, herb-component-common target network and protein interaction network were constructed to study the common mechanism of Xiaoyao Powder in the treatment of depression combined with diabetes from the perspective of “treating different diseases with the same method”. Methods TCM database@Taiwan, TCMID, and Batman-TCM databases were searched and the literature search was conducted to obtain the components and targets of Xiaoyao Powder, and the targets for Xiaoyao Powder in the treatment of depression combined with diabetes were figured out based on CTD, TTD, PharmGKB, OMIM, Gencards, and Drugbank databases. The Cytoscape was applied to plot the herb-component-common target network. The Metascape was used for GO biological process, Reactome pathway, and KEGG pathway analysis, protein interaction network construction and module analysis of the common targets of Xiaoyao Powder in the treatment. The tissue distribution and subcellular distribution of key pathway targets were separately analyzed based on BioGPS and Genecard, and the tissue-target network and subcellular-target network were constructed by the Cytoscape. Protein classification of key pathway targets was performed by DisGeNET. Results The results revealed that the treatment involved the immune and inflammatory responses, which was related to G protein-coupled receptors, insulin and its receptors, and monoamine neurotransmitters, and the efficacy was achieved by regulating cAMP signaling pathway, calcium signaling pathway and PI3 K-Akt signaling pathway. Conclusion The mechanism of Xiaoyao Powder in the treatment of depression combined with diabetes involved the regulation of brain-derived neurotrophic factor (BDNF) signaling pathways, G protein-coupled receptors, monoamine neurotransmitters and insulin and its receptors, which has provided reference for further investigation on antidepressant characteristics of Xiaoyao Powder and its pharmacological mechanism.