Publisher(s): China Academic Journals (CD Edition) Electronic Publishing House Co., Ltd.
ISBN: ISBN 978-7-499-00963-9 pdf
First Published: 2020.11.23
Discipline(s): Medicine & Public Health
Price: $49 (for individuals) (中国大陆地区个人用户点此直接购买)
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Heart Disease (TCM), as part of China’s Medicine Progress Series, has 26 excellent articles on heart disease research with TCM. These articles fully demonstrate the unique therapies and good efficacy of TCM in treating heart diseases, with scientific methodological support and objective conclusions. The original articles were published in Chinese, and this book is a compilation of English versions of the selected articles.
Doctor LIU Jianxun, doctoral supervisor, Qihuang Scholar, principal investigator of China Academy of Chinese Medical Science, and principal scientist of the National Key Basic Research Program (973 Program), has presided over 20 national projects includin
1. Mechanism of Salvianolate injection combined with aspirin in treatment of stable angina pectoris based on biomolecules network
China Journal of Chinese Materia Medica,Part 1: Theoretical Analysis,Vol 41,No. 01
Biomolecular network analysis was used to predict the mechanism of Salvianolate injection combined with aspirin for the treatment of stable angina pectoris (SAP). Related genes of Salvianolate injection, aspirin and SAP were obtained from Genecards, STITCH and Dis Ge NET databases. Agilent literature search software was used to construct biomolecular network; modules were identified by AP, MCODE and MCL methods. DAVID software was used for identification of related KEGG pathways. Results showed that Salvianolate injection and aspirin had a coverage rate of 45.92%, and 62.56% respectively for SAP molecular network, and the coverage rate was 71.64% in combined use. The top 10 important nodes of SAP overlapped with Salvianolate injection and aspirin included MAPK14, MAPK8, IL-6 and IL-8. The important SAP nodes overlapped with Salvianolate injection alone included AKT1 and IFNG, and the important SAP nodes overlapped with aspirin included EPHB2 and TP53. Related SAP signaling pathways with combined Salvianolate injection and aspirin included Jak-STAT signaling pathway and MAPK signaling pathway. Related SAP signaling pathways with Salvianolate injection alone included VEGF signaling pathway and type 1 diabetes signaling pathway. Related SAP signaling pathways with aspirin alone included AA metabolism, linoleic acid metabolism signaling pathway, etc. The results showed that Salvianolate injection and aspirin combination had an enhancement effect in treatment of SAP through anti-inflammatory reaction and inhibition of atherosclerosis development; in addition, the combination use may have an additive effect through the antiplatelet aggregation, protecting endothelial cells, regulating blood lipid and regulating glucose metabolism.
2. Ginseng prescription rules and molecular mechanism in treating coronary heart disease based on data mining and integrative pharmacology
China Journal of Chinese Materia Medica,Part 1: Theoretical Analysis,Vol 43,No. 02
In Shen Nong’s Classic of the Materia Medica, The Grand Compendium of Materia Medica and other works, ginseng has been recorded as top grade with the effect of tonifying primordial qi. It is reported that the main active ingredient of ginseng is ginsenoside according to the literatures. Modern studies have found that ginseng mono saponins are effective for cardiovascular related diseases. This paper preliminary clarified the traditional efficacy of ginseng—nourishing qi and cardiovascular disease through the traditional Chinese medicine (TCM) inheritance auxiliary platform and integrative pharmacology platform. With the help of integrative pharmacology platform—“Chinese medicine database”, the rule of Chinese patent drugs containing Ginseng treating current diseases was discussed, so the traditional effect was associated with modern medicine and pharmacology. Drug target, gene function and metabolic pathway enrichment were analyzed based on integration platform, to further explore the molecular mechanism of ginseng in the treatment of coronary heart disease, aiming at mining the molecular mechanism of ginseng in the treatment of coronary heart disease. National Standard for Chinese Patent Drugs contains 307 ginseng prescriptions, 87 kinds of disease indications, coronary heart disease—disease of Western medicine which is treated by Chinese patent drugs containing Ginseng. Through the analysis of molecular mechanism of integrative pharmacology platform for the treatment of coronary heart disease, 1 556 potential targets were found which were related with the mitochondrial respiratory. Ginsenosides (Ra 1, Ra 2, Rb 1, Rb 2, Rg 1, Ro) bind the targets (PRKAA1, PRKAA2, NDUFA4, COX5B, UQCRC1) to affect chemokines, non-alcoholic fatty liver, gonadotropin, carbon metabolism, glucose metabolism and other pathways, treating coronary heart disease indirectly. The molecular mechanism of Panax ginseng’s multi-component, multi-target and synergistic action is preliminarily elucidated in this paper.
3. Action Mechanism of Linggui Zhugan Decoction for the Treatment of Heart Failure Based on Network Pharmacology
World Chinese Medicine,Part 1: Theoretical Analysis,Vol 14,No. 03
Objective: To explore the potential targets of Linggui Zhugan Decoction for the treatment of heart failure by using network pharmacology. Methods: A bioinformatics analysis website for traditional Chinese medicine (BATMAN-TCM) was used to predict and screen the possible active components of Linggui Zhugan Decoction in the intervention of heart failure and its targets for heart failure. The Cytoscape software was used to construct a target-component network for the treatment of heart failure with Linggui Zhugan Decoction and its single medicines. Venn diagram (Venny 2.1) was used to further study the mechanism of Poria and Radix et Rhizoma Glycyrrhizae of Linggui Zhugan Decoction in the treatment of heart failure. Results: A total of 79 active components in the Linggui Zhugan Decoction were screened out from the results. There were 18 targets associated with heart failure, and the active components and targets were closely related. The 18 targets obtained mainly included: ACE; ADRA2 A; ADRA2 B and so on. The target number of Radix et Rhizoma Glycyrrhizae in Linggui Zhugan Decoction was the largest that it accounted for 94.4%of the total targets of the decoction in the treatment for heart failure. Conclusion: The mechanism of Linggui Zhugan Decoction in improving heart failure may be related to the decrease of Ang II, the inhibition of RAS activity, and the regulation of sympathetic nervous system, etc. Among which, Radix et Rhizoma Glycyrrhizae is the most prominent in the aspect of Linggui Zhugan Decoction in treating heart failure.
4. Study on the mechanism of Radix Salviae Miltiorrhizae–Radix Puerariae in treating coronary heart disease based on network pharmacology
Natural Product Research and Development,Part 1: Theoretical Analysis,Vol 32,No. 04
To explore the mechanism of action of Radix Salviae Miltiorrhizae–Radix Puerariae in treating coronary heart disease (CHD). Based on network pharmacology, the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was retrieved to collect the active ingredients and targets of Radix Salviae Miltiorrhizae–Radix Puerariae. Based on the TDD, DrugBank and Disgenet databases, the targets of CHD were harvested, and the network pharmacology analysis software and related databases were used for establishing the protein–protein interaction (PPI) network, conducting the target enrichment analysis and constructing the active ingredient–target–pathway network. The results showed that 61 active ingredients and 68 common targets were screened out from Radix Salviae Miltiorrhizae and Radix Puerariae. GO analysis showed that Radix Salviae Miltiorrhizae and Radix Puerariae participated in the transcription and inflammation of RNA polymerase II promoter and other biological processes (BPs). The targets were mainly concentrated in the extracellular space, plasma membrane and nucleus. The results of KEGG analysis showed that the Radix Salviae Miltiorrhizae–Radix Puerariae exerted the effects via the signaling pathways such as HIF-10, PI3 K-Akt, TNF and Jak-STAT. Above all, some active ingredients of Radix Salviae Miltiorrhizae–Radix Puerariae, such as tanshinone ⅡA, mignonette and puerarin, played a role of regulating the blood pressure, angiogenesis and inflammation by affecting the HIF-10, PI3K-Akt, TNF and Jak-STAT signal pathways. These pathways were primarily associated with the common targets of TNF, VEGFA, TP53 and IL6. The results of this study have provided a reference for further study of the pharmacological effects of Radix Salviae Miltiorrhizae–Radix Puerariae.