Why does the H. cordata have effects of anti-inflammatory, antitussive and analgesic

Aug. 24,2019
Print Language:

Herba Houttuyniae refers to the fresh whole grass or dried aboveground part of Houttuynia cordata Thunb., a plant in family Saururaceae. It is slightly cold in nature and pungent in taste, with the efficacy of clearing away heat, removing toxin, expelling abscess, evacuating pus, inducing diuresis, relieving strangurtia, which can be used for the treatment of pyemesis due to lung abscess, phlegm heat and dyspnea with cough, heat dysentery, heat stranguria, abscess, swelling, sores and toxin . According to reports, the alkaloids isolated from H. cordata mainly include aporphine alkaloid, piperolactam, aristololactam and cepharadione. Among them, piperolactam and aristololactam have inhibitory effects on the proliferation of five human cancer cell lines in vitro .

The chloroform extract of H. cordata had significant anti-inflammatory, antitussive and analgesic effects, what is it made of?

Chemical constituents in chloroform fraction of Houttuynia cordata by YANG Xiao-lu et al., conducted the systematic research on its chemical constituents in chloroform fraction after carrying out the alkaloid extraction of H. cordata and purification as well as exploring its mechanism against human lung cancer cell line H460.

The result shows that: The comparative study on the pharmacological activities of different extraction fractions of H. cordata revealed that the chloroform fraction of H. cordata had significant anti-inflammatory, antitussive and analgesic effects. nine compounds were isolated from the chloroform fraction of H. cordata by the authors. Compared with compound 2, compound 1 had one less methyl group. Its pharmacological activity and structure-activity relationship remain to be further explored. Compound 5 had a low toxicity against mouse macrophages, and compound 8 showed no cytotoxic activity against tumor cell lines ovarian cancer, lung cancer and melanoma. Compound 6 had a certain anti-inflammatory activity and it was able to inhibit the LPS-induced NO release from microglial BV2 cells in mice.

Corresponding Author: YANG Xiao-lu
Email:
CNKI Press Officer: ZHONG Ming
Email: zm6946@cnki.net

Disclaimer: Some of the images in this website are derived of the public network, whose copyrights still belong to the authors. If there exist any infringements, please contact us to delete them