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短穗兔耳草化学成分研究

朱继孝1 史亚夫1 程虹毓2 王洪玲1 王瑞1 李敏1

(1.江西中医药大学中药资源与民族药研究中心, 江西南昌 330004)
(2.江西中医药大学人文学院, 江西南昌 330004)

【摘要】目的:研究短穗兔耳草的化学成分。方法:短穗兔耳草以75%乙醇提取,并采用硅胶柱层析、Sephadex LH-20、制备液相色谱、ODS等色谱柱和重结晶等方法进行分离纯化,通过波谱解析进行化学结构鉴定。结果:从短穗兔耳草中分离得到11个化合物,分别鉴定为:scutellariosidⅡ(1)、globularimin(2)、baldaccioside(3)、10-O-反式-异阿魏酰基梓醇(4)、8-epi-loganic acid(5)、木犀草素-7-O-β-D-吡喃葡萄糖苷(6)、小麦黄素-7-O-β-D-吡喃葡萄糖苷(7)、木犀草素(8)、hemiphroside B(9)、车前草苷D(10)、苯甲醇-O-(2′-O-β-D-吡喃木糖基)-β-D-吡喃葡萄糖苷(11)。结论:其中,化合物3、4、9、10、11为首次从该属植物中分离得到,化合物1、2、5、7为首次从该植物中分离得到。

【关键词】 短穗兔耳草;化学成分;结构鉴定;

【DOI】

【基金资助】 国家自然科学基金(81660702); “江西民族药现代科技与产业发展协同创新中心”开放基金(J XXT2017004);

Chemical Constituents from Lagotis brachystachy

ZHU Ji-xiao1 SHI Ya-fu1 CHENG Hong-yu2 WANG Hong-ling1 WANG Rui1 LI Min1

(1.Research Center of Chinese Herbal Medicine and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, China 330004)
(2.School of Humanities, Jiangxi University of Traditional Chinese Medicine, Nanchang, China 330004)

【Abstract】Objective: To study the chemical constituents of Lagotis brachystachy. Methods: L. brachystachy was extracted with 75% ethanol and isolated and purified by silica gel, Sephadex LH-20, preparative liquid chromatography, ODS column chromatography, and recrystallization. The chemical structures were identified by spectrum analysis. Results: Eleven compounds were isolated and identified as scutellariosid II (1), globularimin (2), baldaccioside (3), 10-O-trans-isoferoylcatalpol (4), 8-epi-loganic acid (5), luteolin-7-O-β-D-glucopyranoside (6), tricin-7-O-β-D-glucopyranoside (7), luteolin (8), hemiphroside B (9), plantaginin D (10), benzyl alcohol-O-(2′-O-β-D-pyranoxylol)-β-D-glucopyranoside (11). Conclusion: Compounds 3, 4, 9, 10, and 11 are isolated from the Logotis genus for the first time. Compounds 1, 2, 5, and 7 are isolated from L. brachystachy for the first time.

【Keywords】 Lagotis brachystachy Maxim.; Chemical constituents; Structural identification;

【DOI】

【Funds】 National Natural Science Foundation of China (81660702); Open Fund of Jiangxi Collaborative Innovation Center of Modern Technology and Industrial Development of Ethnic Medicine (JXXT2017004);

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This Article

ISSN:1001-4454

CN: 44-1286/R

Vol 42, No. 03, Pages 552-555

March 2019

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Article Outline

Abstract

  • 1 Instruments and materials
  • 2 Extraction and isolation
  • 3 Structure identification
  • References