Fabrication of metal nanocomposites based on proteins and their self-assemblies as templates

LIANG Miao1,2 YU Tao1 GAO Xiang3 SU Rongxin1 QI Wei1 HE Zhimin1

(1.State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China 300072)
(2.School of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou, Henan, China 450001)
(3.State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang, China 310027)

【Abstract】Fabrication of functional metal nanocomposites by using protein and its self-assemblies as template has aroused the interest of the researchers. Protein and its self-assemblies generally exhibit various morphological structures and possess specific molecular recognition as well as biomimetic mineralization capabilities. These characteristics make them play an important role of structural orientation and morphology control during the assisted synthesis of metal nanostructures. And the fabricated protein–metal nanostructure composites exhibit broad prospect of applications in catalytic conversion, biosensing, medical imaging and so on. Based on the differences in structural characteristics of proteins and their assemblies, this review summarizes the recent progress in the construction of metal nanocomposites based on protein single subunits, protein multi-subunit super assembled structures and three-dimensional protein crystals. The direction of research and development is forecasted. Furthermore, the future research direction in this field is prospected.

【Keywords】 protein; self-assembly; protein crystal; metal nanostructure; composite materials;


【Funds】 National Natural Science Foundation of China (51473115) State Key Laboratory of Chemical Engineering (SKL-ChE-14T04) Natural Science Foundation of Tianjin City (16JCZDJC37900)

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This Article


CN: 11-1946/TQ

Vol 69, No. 11, Pages 4553-4565+4930

November 2018


Article Outline


  • Introduction
  • 1 Metal nanomaterials based on protein single subunit structure
  • 2 Metal nanomaterials based on protein multi-subunit super assembled structure
  • 3 Metal nanomaterials based on protein crystal structure
  • 4 Conclusion and prospect
  • References