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Chemical Constituents Analysis in Chinese Herbs

Chemical Constituents Analysis in Chinese Herbs

A new iridoid from Valeriana officinalis var. latiofolia

WANG Jin-xin;HAN Zhu-zhen;LI Hui-liang;ZHANG Wei-dong

Chinese Traditional and Herbal Drugs,Vol 46,No. 01

【Abstract】 Objective To investigate the chemical constituents in the roots of Valeriana officinalis var. latiofolia collected from Guizhou province, China. Methods The compounds 1–6 were separated and purified by column chromatography with silica gel, RP C18, Sephadex LH-20, and preparative TLC. Their structures were elucidated on the basis of spectroscopic (MS, NMR, etc.) methods and chemical evidences. Results Six compounds were isolated from ethyl acetate fractions of 95% ethanol extract of the root of V. officinalis var. latiofolia and identified as iridoids: valeriridoid P (1); dihydroxymaaliane (2), and madolin F (3); madolin A (4), volvalerenal B (5), and kissoone A (6), respectively. Conclusion Compound 1 is a new iridoid with two oxo-bridges, and compounds 2–6 are known compounds.

Study on Chemical Constituents of Kalimeris indica

WANG Guo-kai;LIU Jin-song;ZHANG Cong-er;WANG Zheng;CAI Bai-xiang;WANG Gang

Journal of Chinese Medicinal Materials,Vol 38,No. 01

【Abstract】 Objective: To study the chemical constituents from Kalimeris indica. Methods: The chemical structures were identified by pob data which can be obtained by many methods of silica gel, Sephadex LH-20 and preparing HPLC, etc. Results: Fourteen compounds were isolated and identified as α-spinasterol(1), dibutylphthalate(2), (22 E, 24R)-5α, 8α-epidioxy-ergosta-6, 22-dien-3β-ol(3), oleanolic acid(4), coniferyl alcohol(5), umbelliferone(6), syringaresinol(7), 15-oxo-14, 16H-strictic acid(8), lariciresinol(9), (Z)-3, 7, 11-trimethyl-1, 6-dodecadien-3, 10, 11-triol(10), neoechinulin A(11), pinoresinol(12), 4-allyl-3, 5-dimethoxyphenol(13), and 3, 4, 5-trimethoxyacetophenone(14). Conclusion: Except compound 1, the other compounds are isolated from this platymiscium for the first time.

Study on Chemical Constituents from Hypocotyls of Mangrove Bruguiera gymnorrhiza

YI Xiang-xi;GAO Cheng-hai;LONG Bin;SU Zhi-wei;YU Lian;HE Bi-juan

Journal of Chinese Medicinal Materials,Vol 38,No. 01

【Abstract】 Objective: To study the chemical constituents from the hypocotyls of mangrove Bruguiera gymnorrhiza. Methods: The chemical constituents were isolated and purified by recrystallization, silica gel column chromatography and semi-preparative HPLC. Their structures were identified by spectroscopic analysis and comparison with literatures. Results: Seven compounds were isolated and their structures were identified as 3-β-(Z)-coumaroyllupeol (1), dioslupecin(2), cholesterol (3), menisdaurillide(4), aquilegiolide (5), vomifoliol (6) and roseosideⅡ (7). Conclusion: Compounds 1, 2 and 4–7 are isolated from this plant for the first time.

Study on Chemical Constituents of Petroleum Ether Fraction from Rubus alceaefolius

CHEN Pan;FANG Zhi-jian;YAN Han-jing;ZHOU Hong-bo;MEI Quan-xi

Journal of Chinese Medicinal Materials,Vol 38,No. 01

【Abstract】 Objective: To investigate the chemical constituents of Rubus alceaefolius. Methods: Nine compounds were isolated and purified from the petroleum ether extract of 95% alcohol extract of Rubus alceaefolius by repeated column chromatography on silica, Sephadex LH-20 and structurally identified by spectral analysis. Results: The compounds were identified as chrysophanol (1), physcion(2), β-sitosterol (3), 3-oxotirucalla-7,24-dien-21-oic acid (4), myricadiol (5), 19-α-hydroxy-3-acetyl-ursolic acid(6), N-benzoylphenylalaninyl-N-benzoylphenylalaninate (7), aurantiamide acetate (8) and euscaphic acid (9). Conclusion: Compounds 1 and 4–8 are isolated from this plant for the first time,and compounds 4–8 are found in plants of Rubus genus for the first time.

Chemical Constituents from Cynanchum paniculatum

FU Ming;WANG Deng-yu;HU Xing;GUO Meng-qi

Journal of Chinese Medicinal Materials,Vol 38,No. 01

【Abstract】 Objective: To investigate the chemical constituents from Cynanchum paniculatum. Methods: The constituents were isolated and purified by silica gel, Sephadex LH-20 column chromatography, and preparative TLC. Their structures were identified on the basis of spectral data and physiochemical characteristics. Results: 15 compounds were isolated from 70% ethanol extract and identified as β-sitosterol (1), β-daucosterin (2), mudanoside A (3), paeonolide (4), santamarin (5), paeonol (6), annobraine (7), laricircsinol (8), α-asarone (9), 7-angelyheliotridine (10), β-amyrin (11), uridine (12), kaempferol-3- O-β-D-glucopyranosyl (1 →2)- α-L-arabinopyranoside (13), kaempferol-7- O-(4″,6″-di-p-hydroxycinnamoyl-2″,3″-diacetyl)- β-D-glucopyranoside (14), and (2 S, E)-N-[2-hydroxy-2-(4-hydroxyphenyl) ethyl]ferulamide (15). Conclusion: Compounds 4,6,8,11,12 and 15 are isolated from this plant for the first time, Compounds 5 and 14 are firstly isolated from the plants of Cynanchum genus.

Phenylpropanoids from Saussureae hieracioides

WANG Yu-jie;TAN Rong;ZHOU Li-shi;GU Rui;ZHANG Yi

Journal of Chinese Medicinal Materials,Vol 38,No. 01

【Abstract】 Objective: To isolate and identify the phenylpropanoids from Saussurea hieracioides. Methods: The compounds were isolated by chromatographic and their structures were elucidated on the basis of spectra data. Results: Seven compounds were isolated and identified as umbelliferone (1), scopoletin (2), caffeic acid (3), esculetin (4), skimmin (5), scopolin (6) and chlorogenic acid (7), respectively. Conclusion: Compounds 3, 4 and 7 were isolated from this plant for the first time.

Caffeic acids from roots of Arctium lappa and their neuroprotective activity

BAI Jun-peng;HU Xiao-long;JIANG Xiao-wen;TIAN Xing;ZHAO Qing-chun

Chinese Traditional and Herbal Drugs,Vol 46,No. 02

【Abstract】 Objective To investigate the caffeic acid compounds from the roots of Arctium lappa and their neuroprotective activity. Methods The compounds were isolated by column chromatography over silica gel, octadecylsilane (ODS) chemically bonded silica gel, Sephadex LH-20, and AB-8 macroporous resin coupled with preparative HPLC. Their structures were elucidated by spectroscopic analysis and their neuroprotective activity against glutamate-induced neurotoxicity was evaluated in SH-SY5 Y cells by MTT assay. Results Eight caffeic acid compounds were isolated from the roots of A. lappa, which were identified as 1, 5-O-dicaffeoyl-3-O-(4-malic acid methyl ester)-quinicacid (1), 3, 5-O-dicaffeoyl-quinic acid methyl ester (2), 3, 4-O-dicaffeoyl-quinic acid methylester (3), 4, 5-O-dicaffeoyl-quinic acid methyl ester (4), (2E)-1, 4-dimethyl-2-[(4-hydroxyphenyl)methyl]-2-butenedioicacid (5), chlorogenic acid methyl ester (6), caffeic acid mtheyl ester (7), and 3, 4, 3′, 4′-tetrahydroxy-δ-truxinate (8). In vitro, these compounds showed the neuroprotective activity against glutamate-induced neurotoxicity on different levels. Conclusion The neuroprotective activity of the roots in A. lappa against glutamate-induced neurotoxicity is related to the caffeic acid compounds. Compound 1 is a new compound;Compound 5 is a new natural compound; Compounds 2–7 are isolated from A. lappa for the first time;Compound 8 is isolated from the plants of Arctium L. for the first time.

Triterpenoids from Leaves of Ilex latifolia

WANG Cun-qin;WANG Hong-ting;XU Hao;SHI Yan-ping

Journal of Chinese Medicinal Materials,Vol 38,No. 08

【Abstract】 Objective: To investigate the chemical constituents from the leaves of Ilex latifolia. Methods: The constituents were isolated and purified by various chromatographic techniques. Their structures were identified by UV, IR, MS and NMR spectroscopic analysis. Results: Ten compounds were isolated from the leaves of Ilex latifolia. Their structures were respectively identified as 3β, 13β-dihydroxy-urs-11-en-28-oic acid-13-lactone (1), β-sitosterol (2), 3-hydroxy-11-oxours-12-ene (3), (20S, 24S)-epoxydammarane-3β, 25-diol (4), 25-deuteriostigmasterol (5), α-amyrin (6), foliasalacin A4 (7), 23-hydroxyursolic acid (8), p-coumaric acid (9), and β-daucosterol (10). Conclusion: Compounds 1, 3–5, 7 and 9 are isolated from this plant for the first time.

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