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Breast Cancer

Thunder-fire Moxibustion for Qi Deficiency-induced Fatigue in Breast Cancer Patients Under-going Chemotherapy

LU Lu;LI Wei-han;GUO Xiao-chuan;FU Wen-bin

Acupuncture Research,Vol 43,No. 02

【Abstract】 Objective To observe the clinical effect of thunder-fire moxibustion in the treatment of qi deficiency-induced fatigue in breast cancer patients undergoing chemotherapy. Methods Sixty breast cancer patients undergoing chemotherapy were randomly divided into thunder-fire moxibustion (Moxi) and conventional nursing (nursing) groups ( n = 30 in each group). Patients in the Moxi group were treated with thunder-fire moxibustion applied to the back part of body from Pishu (BL20) to Qihaishu (BL24) on the bilateral sides and to the abdominal part from Zhongwan (CV12) to Guanyuan (CV4) for 30 min, once a day for 14 days. Patients in the nursing group were treated with health education and conventional nursing care. The simple fatigue scale, traditional Chinese medicine (TCM) syndrome score, clinical curative effect were observed before and after the treatment, and white blood cell (WBC) count was observed 5 days after chemotherapy and after the treatment respectively. Results After the treatment, the simple fatigue scales and TCM syndrome scores were significantly decreased and WBC counts were significantly increased in both groups relevant to their individual pre-treatment ( P < 0.01). The therapeutic effect of the Moxi group was apparently superior to that of the nursing group in lowering the simple fatigue scale and TCM syndrome score and in up-regulating WBC count ( P < 0.01, P < 0.05). The total effective rate of the Moxi group was significantly higher than that of the nursing group (83.3% [25/30] vs. 36.7% [11/30], P < 0.01). Conclusion Thunder-fire moxibustion can effectively relieve the degree of fatigue and the symptoms of qi deficiency in breast cancer patients undergoing chemotherapy.

In Vitro Anticancer Effect of Combretastatin A4 Liposomes in Destruction of Vascular Mimicry in Triple-Negative Breast Cancer Cells

LIU Han;HUANG Dan;GUO Yang;ZHANG Xuan

Chinese Pharmaceutical Journal,Vol 53,No. 04

【Abstract】 OBJECTIVE To investigate the potential anticancer effect of combretastatin A4 liposomes (SSL-CA4) in destruction of vascular mimicry (VM) in MDA-MB-231 breast cancer cells in vitro. METHODS The in vitro inhibitory effect and blocking woundhealing effect of SSL-CA4 were investigated. The VM destruction of SSL-CA4 was evaluated in three dimensional matrigel culture model in MDA-MB-231 cells. The in vitro inhibitory test showed that the maximum inhibition ratio of SSL-CA4 on MDA-MB-231 cells was close to 50%. SSL-CA4 blocked the wound-healing of MDA-MB-231 cells, which was similar to that of free CA4. RESULTS SSL-CA4 could inhibit the formation of VM in vitro via inhibition on the VM channel indicators including hypoxia-inducible factor (HIF-α), vascular endothelial-cadherin (VE-Cad), and matrix metallopeptidases (MMP-2). The inhibition on indicators of SSL-CA4 was significantly higher than those in the CA4 treatment groups ( P < 0.05). CONCLUSION SSL-CA4 has significant anticancer activity via inhibition of VM in MDA-MB-231 cell line.

Co-culture of human breast adenocarcinoma cells and human umbilical vein endothelial cells to mimic in vivo tumor microenvironment

YANG Yan-fang;MENG Ying-ying;YE Jun;XIA Xue-jun;LI Lin;DONG Wu-jun;WANG Hong-liang;LIU Yu-ling

Acta Pharmaceutica Sinica,Vol 53,No. 03

【Abstract】 The development of tumor tissue is a complicated process, which is closely related to tumor microenvironment. In order to simulate the tumor tissue in vivo, non-contact co-culture of human breast adenocarcinoma cells (MCF-7 cells) and human umbilical vein endothelial cells (HUVECs cells) using transwell cell culture plate was developed in this study. The cell viability, morphology, cell resistance, cell cycle and vascular endothelial growth factor (VEGF) protein content of co-cultured MCF-7 and HUVECs cells were investigated, and compared with those of separately cultivated MCF-7 and HUVECs cells during the same period. Different to the separately cultured MCF-7 and HUVECs cells, co-cultured MCF-7 and HUVECs cells exhibited higher cell viability, deformed cell morphology, lower cell resistance, higher proportion of S and G 2/M phases and higher VEGF protein content (about 1.4–2 times). The double cell model via non-contact co-culture of MCF-7 and HUVECs cells constructed in this study could simulate the interaction between tumor cells and tumor vascular endothelial cells in vivo, which may provide a more realistic model for subsequent study of drug release system in the control of breast cancer in vitro.

Design and clinical application of rehabilitation VR system for breast cancer patients

JIN Ai-xiang;CHEN Xiao-min ;ZHANG Xiaofei ;CHEN Jie

Chinese Journal of Nursing,Vol 53,No. 02

【Abstract】 With the application and integration of high-quality computer software and hardware as well as the advanced sensors, a rehabilitation VR system has been explored and developed for breast cancer patients. According to the changes of lymphedema and motor function, the rehabilitation process was divided into four phases. After a three-month control experiment among 76 cases of breast cancer patients, the results showed that the VR system with auxiliary game treatment to control patients’ training process was able to substantially improve limb function recovery, compliance and subjective initiative in rehabilitation training, and reduce the edema of affected limbs, and the differences were statistically significant ( P < 0.01, P < 0.05) . Therefore, the VR system helps patients’ limb function recovery and reduce negative emotions after surgery.

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